Alcohol consumption at the time of conception and spontaneous abortion
Alcohol consumption at the time of conception and spontaneous abortion
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DOI：
10.1093/aje/kwh259
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发表时间：
2004-10-01
影响因子：
5
通讯作者：
Olsen, J
中科院分区：
文献类型：
--
作者：
Henriksen, TB;Hjollund, NH;Olsen, J
作者研究了女性和男性在怀孕期间的酒精摄入量与自然流产风险之间的关系，包括通过尿人绒毛膜促性腺激素检测的早期妊娠流产。在1992年至1994年期间，丹麦向四个工会的约5万名成员邮寄了一份全国范围内的邮件，在停止避孕措施后，430对以前没有怀孕过的夫妇被登记在案，直到临床确认怀孕或六个月经周期。在每月的调查问卷中报告了酒精摄入量和潜在的混杂因素。妇女从每个周期阴道出血的第一天开始收集10天的晨尿。作者检测到186例妊娠：131例分娩，55例自然流产（34例通过尿人绒毛膜促性腺激素检测）。根据不同的孕期摄入量和调节因素，女性饮酒与未饮酒的自然流产校正风险相关2-3倍，男性饮酒与自然流产校正风险相关2-5倍。只有每周饮酒10次或以上与不饮酒相比，调整后的相对风险具有统计学意义。男性和女性在怀孕一周内饮酒都会增加早期妊娠流产的风险。
The authors studied the association between female and male alcohol intakes at the time of conception and the risk of spontaneous abortion, including early pregnancy loss detected by urinary human chorionic gonadotropin. After a nationwide mailing to about 50,000 members of four trade unions in Denmark in 1992-1994, 430 couples without previous pregnancy attempts were enrolled when birth control was discontinued, and they were followed until a clinically recognized pregnancy or for six menstrual cycles. Alcohol intake and potential confounding factors were reported in monthly questionnaires. Women collected morning urine for 10 days from the first day of vaginal bleeding in each cycle. The authors detected 186 pregnancies: 131 resulted in childbirth, and 55 resulted in spontaneous abortion (34 detected by urinary human chorionic gonadotropin). Depending on the intake in the cycle of conception and the adjustment factors, female alcohol intake was associated with 2-3 times the adjusted risk of spontaneous abortion compared with no intake, and male alcohol intake was associated with 2-5 times the adjusted risk. Only the adjusted relative risks for 10 or more drinks/week compared with no intake were statistically significant. Both male and female alcohol intakes during the week of conception increased the risk of early pregnancy loss.