Addressing reverse inference in psychiatric neuroimaging: Meta-analyses of task-related brain activation in common mental disorders.
Addressing reverse inference in psychiatric neuroimaging: Meta-analyses of task-related brain activation in common mental disorders.
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DOI：
10.1002/hbm.23486
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发表时间：
2017-04
影响因子：
4.8
通讯作者：
Frangou S
中科院分区：
文献类型：
--
作者：
Sprooten E;Rasgon A;Goodman M;Carlin A;Leibu E;Lee WH;Frangou S
精神病学中的功能磁共振成像（fMRI）研究使用各种任务来识别任务相关大脑激活模式的病例对照差异。不同的激活区域通常被归因于疾病特异性功能，试图将疾病表达和大脑功能联系起来。我们对任务功能磁共振成像研究的数据进行了系统的荟萃分析，以检查诊断和研究设计对病例对照差异对大脑激活的空间分布和方向的影响。我们将来自 537 项精神分裂症、双相情感障碍、重度抑郁症、焦虑症和强迫症任务-fMRI 研究的病例对照差异坐标映射到图谱区域坐标，这些研究包括来自 21,427 名参与者的观察结果。 fMRI 任务根据研究领域标准 (RDoC) 进行分类。我们研究了诊断、RDoC 域或感兴趣区域或全脑分析的构建和使用是否影响结果的神经解剖模式。在考虑所有初步研究时，我们发现了杏仁核和尾状核的诊断效果以及 RDoC 结构域和杏仁核、海马、壳核和伏核的结构的效果。相比之下，全脑研究没有发现诊断或 RDoC 结构域或结构有任何显着影响。这些结果与先前关于这些疾病的常见大脑结构和遗传基础的报告产生了共鸣，并警告在形成精神疾病的解释模型时不要将过度的特异性归因于大脑功能的变化。 Hum Brain Mapp 38:1846–1864, 2017。© 2017 Wiley periodicals, Inc.
Functional magnetic resonance imaging (fMRI) studies in psychiatry use various tasks to identify case‐control differences in the patterns of task‐related brain activation. Differently activated regions are often ascribed disorder‐specific functions in an attempt to link disease expression and brain function. We undertook a systematic meta‐analysis of data from task‐fMRI studies to examine the effect of diagnosis and study design on the spatial distribution and direction of case‐control differences on brain activation. We mapped to atlas regions coordinates of case‐control differences derived from 537 task‐fMRI studies in schizophrenia, bipolar disorder, major depressive disorder, anxiety disorders, and obsessive compulsive disorder comprising observations derived from 21,427 participants. The fMRI tasks were classified according to the Research Domain Criteria (RDoC). We investigated whether diagnosis, RDoC domain or construct and use of regions‐of‐interest or whole‐brain analyses influenced the neuroanatomical pattern of results. When considering all primary studies, we found an effect of diagnosis for the amygdala and caudate nucleus and an effect of RDoC domains and constructs for the amygdala, hippocampus, putamen and nucleus accumbens. In contrast, whole‐brain studies did not identify any significant effect of diagnosis or RDoC domain or construct. These results resonate with prior reports of common brain structural and genetic underpinnings across these disorders and caution against attributing undue specificity to brain functional changes when forming explanatory models of psychiatric disorders. Hum Brain Mapp 38:1846–1864, 2017. © 2017 Wiley Periodicals, Inc.