Diagnosis of cystic fibrosis in the Republic of Ireland: epidemiology and costs.
Diagnosis of cystic fibrosis in the Republic of Ireland: epidemiology and costs.
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发表时间：
2007-09
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通讯作者：
Philip M. Farrell;Steven Joffe;Linda Foley;Gerrard J Canny;Philip Mayne;Marjorie A. Rosenberg
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作者：
Philip M. Farrell;Steven Joffe;Linda Foley;Gerrard J Canny;Philip Mayne;Marjorie A. Rosenberg
本研究有四个目标：（1）确定爱尔兰囊性纤维化（CF）的发病率；（2）估算CF诊断成本；（3）阐明全国性诊断工作的特点和结果；（4）识别差异。通过调查确定了2001年至2003年爱尔兰汗液检测的数量、方法、成本和结果。结果使我们能够确定爱尔兰的CF发病率为1:1353，是世界上最高的。平均诊断成本为每位患者2663欧元。对爱尔兰囊性纤维化登记处数据的分析显示，当诊断依据呼吸系统症状而非胃肠道症状时，诊断延迟时间更长，而且女孩比男孩的延迟时间更长，尤其是那些出现呼吸系统症状的女孩。尽管爱尔兰CF诊断费用相对适中，但较高的发病率、诊断年龄以及性别相关的差异，足以证明对全国新生儿筛查进行投资是合理的。
There were four objectives in this study: (1) determine the incidence of cystic fibrosis (CF) in Ireland; (2) estimate the cost of diagnosing CF; (3) clarify the characteristics and outcomes of the nationwide diagnostic efforts and (4) identify disparities. Surveys were conducted to determine the number, methods, costs and outcomes for sweat tests in Ireland from 2001 through 2003. The results allowed us to determine that Ireland's CF incidence is the world's highest at 1:1353. The average cost for diagnosis was Euro 2663 per patient. Analyses of data in The Cystic Fibrosis Registry of Ireland revealed longer delays when diagnosis followed respiratory symptoms, rather than gastrointestinal signs, and also in girls compared to boys, particularly those presenting with respiratory symptoms. Although expenditures for diagnosing of CF in Ireland are relatively modest, the high incidence and age of diagnosis, as well as gender-related disparities, are sufficient to warrant investment in national newborn screening.