CXCR3 antagonist AMG487 ameliorates experimental autoimmune prostatitis by diminishing Th1 cell differentiation and inhibiting macrophage M1 phenotypic activation
CXCR3 antagonist AMG487 ameliorates experimental autoimmune prostatitis by diminishing Th1 cell differentiation and inhibiting macrophage M1 phenotypic activation
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DOI：
10.1002/pros.24395
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发表时间：
2022-06
期刊：
影响因子：
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通讯作者：
X. Hua;Jiong Zhang;Shengdong Ge;Haoran Liu;Hexi Du;Qingsong Niu;Xianguo Chen;Cheng Yang;Li Zhang;C. Liang
中科院分区：
文献类型：
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作者：
X. Hua;Jiong Zhang;Shengdong Ge;Haoran Liu;Hexi Du;Qingsong Niu;Xianguo Chen;Cheng Yang;Li Zhang;C. Liang
慢性前列腺炎和慢性盆腔疼痛综合征(CP/CPPS)是一种以前列腺癌和盆腔炎性细胞或会疼痛为特征的炎症性免疫性疾病。CXCR3受体调节免疫和炎症反应；然而，CXCR3拮抗剂AMG487在CP/CPPS中的作用尚不清楚。因此，我们研究了AMG487对实验性自身免疫性前列腺炎(EAP)小鼠的影响，并探讨了其可能的作用机制。
Chronic prostatitis and chronic pelvic pain syndrome (CP/CPPS) is an inflammatory immune disease that is characterized by infiltrating inflammatory cells in the prostate and pelvic or by perineal pain. Receptor CXCR3modulates immune and inflammatory responses; however, the effects of CXCR3 antagonist AMG487 in the context of CP/CPPS are unknown. Therefore, we investigated the effect of AMG487 in experimental autoimmune prostatitis (EAP) mice and explored the potential functional mechanisms.