Pharmacology of sucrose-reinforced place-preference conditioning: Effects of naltrexone
Pharmacology of sucrose-reinforced place-preference conditioning: Effects of naltrexone
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DOI：
10.1016/s0091-3057(99)00251-8
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发表时间：
2000-04-01
影响因子：
3.6
通讯作者：
Bodnar, RJ
中科院分区：
文献类型：
--
作者：
Delamater, AR;Sclafani, A;Bodnar, RJ
两个实验研究了阿片系统在大鼠蔗糖强化条件性位置偏爱（CPP）中的作用。实验1研究了一般阿片类拮抗剂纳洛酮对在无药物情况下获得的CPP表达的影响。受试者接受培训，将双室室的一个室与蔗糖相关联，另一个室与水相关联。在溶剂盐水处理后，在没有糖或水的情况下，大鼠在选择试验中显示出对蔗糖相关隔室的偏好。2.5和5.0 mg/kg的纳洛酮剂量降低了对蔗糖相关隔室的这种偏好。实验二考察了纳洛酮对CPPS获得和表达的影响。不同组的大鼠每天接受生理盐水、0.1.在每次训练前分别注射纳洛酮1.0、5.0mg/kg，然后分别注射生理盐水或纳洛酮后进行选择性CPP试验。虽然纳洛酮治疗减弱了CPP的表达，在每组相对于生理盐水治疗，有没有组差异，在这些测试中的程度的喜好。此外，尽管纳洛酮剂量依赖性地降低了训练阶段的蔗糖摄入量，但所有组均显示出相同的CPP获得。总之，结果表明，阿片系统调节表达，但不收购蔗糖增强CPP。(C)2000 Elsevier Science Inc.
Two experiments investigated the role of the opioid system in sucrose-reinforced conditioned place preferences (CPPs) in rats. Experiment 1 examined the effects of a general opioid antagonist, naltrexone, on the expression of a CPP acquired in the absence of the drug. Subjects were trained to associate one compartment of a two-compartment chamber with sucrose and the other compartment with water. Rats displayed a preference for the sucrose-associated compartment in a choice test without sugar or water available following vehicle saline treatment. Naltrexone doses of 2.5 and 5.0 mg/kg reduced this preference for the sucrose-associated compartment. Experiment 2 examined the effects of naltrexone on the acquisition as well as the expression of CPPS. Different groups of rats received daily injections of either saline, 0.1. 1.0, or 5.0 mg/kg of naltrexone prior to each training session, and then these groups were given a choice test for the CPP after saline or naltrexone injections. Although naltrexone treatment attenuated the expression of CPPs in each group relative to saline treatment, there were no group differences during these tests in the magnitude of the preferences. Moreover, all groups displayed equal acquisition of CPPs despite the fact that naltrexone dose dependently decreased sucrose intake during the training phase. Together, the results indicate that the opioid system modulates the expression but not the acquisition of sucrose-reinforced CPPs. (C) 2000 Elsevier Science Inc.