Effect of folic acid on methotrexate induction of sulfotransferases in rats.
Effect of folic acid on methotrexate induction of sulfotransferases in rats.
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DOI：
10.2174/187231208784040997
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发表时间：
2008-04-01
影响因子：
--
通讯作者：
Chen, Guangping
中科院分区：
文献类型：
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作者：
Dutta, Sangita Maiti;Maiti, Smarajit;Chen, Guangping
我们早期的研究表明，MTX是一种诱导剂的大鼠和人类磺基转移酶。在这里，我们报告叶酸治疗抑制MTX诱导芳基磺基转移酶（AST-IV）在雌性大鼠肝脏和羟基类固醇磺基转移酶（STa）在雄性大鼠肝脏。这对于理解MTX的临床机制是重要的。
Our earlier investigation showed that MTX is an inducer of rat and human sulfotransferases. Here we report that folic acid treatment inhibited MTX induction of aryl sulfotransferase (AST-IV) in female rat liver and hydroxysteroid sulfotransferase (STa) in male rat liver. This is important for understanding the clinical mechanisms of MTX.