Dengue Virus is Hyperendemic in Nigeria from 2009 to 2020: A Contemporary Systematic Review.
Dengue Virus is Hyperendemic in Nigeria from 2009 to 2020: A Contemporary Systematic Review.
复制标题
2009-2020年登革热病毒在尼日利亚的高度流行：当代系统评价。
DOI：
10.3947/ic.2020.0142
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发表时间：
2021-06
影响因子：
4.2
通讯作者：
Oyewusi S
中科院分区：
文献类型：
--
作者：
Emeribe AU;Abdullahi IN;Isong IK;Emeribe AO;Nwofe JO;Shuaib BI;Gwarzo AM;Usman Y;Sadi M;Umeozuru CM;Dangana A;Egenti BN;Mallam MAB;Emelonye AU;Aminu MS;Yahaya H;Oyewusi S
登革病毒（DENV）感染流行率，地理分布和风险因素的数据是必要的，以指导适当利用现有的和新的控制策略。本研究旨在确定2009年1月1日至2020年12月31日期间尼日利亚DENV感染的合并患病率、危险因素和循环血清型。在2，215篇可用文章中，有21项研究符合条件，并纳入本系统性综述。根据系统性综述和荟萃分析的首选报告项目（PRISMA）标准，对相关文章进行检索、筛选并纳入本研究。采用科克伦方法评估主要研究的偏倚风险。采用卡方检验计算合并患病率的异质性，卡方检验采用科克伦Q统计量，Q统计量由I方值量化。比例的随机效应分析用于确定来自合格研究的DENV抗体、抗原和RNA的合并患病率。其中，3项研究报告了所有4种血清型的共循环，而2项分别报告了DENV-1和2以及DENV-1至-3的共循环。所有基于抗体的研究均具有显著的高异质性（I2> 90%，P <0.05），而基于NS1和PCR的研究具有低异质性（I2 <25%，P> 0.05）。登革病毒IgM、IgG、RNA、NS1和中和抗体的总检出率分别为16.8%、34.7%、7.7%、7.7%和0.7%。尼日利亚东南部的DENV-IgG血清阳性率最高，为77.1%。婚姻状况、性别、文化程度和职业、居住地离垃圾场近、经常穿长裤和长袖衬衫与DENVIgG阳性率显著相关（P <0.05）。根据这些发现，可以推断尼日利亚是登革热的高流行区，需要协同努力控制其在国内外的传播。
Data on Dengue virus (DENV) infection prevalence, geographic distribution and risk factors are necessary to direct appropriate utilization of existing and emerging control strategies. This study aimed to determine the pooled prevalence, risk factors of DENV infection and the circulating serotypes within Nigeria from January 1, 2009 to December 31, 2020. Twenty-one studies out of 2,215 available articles were eligible and included for this systematic review. Relevant articles were searched, screened and included in this study according to the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) criteria. The risk of bias in primary studies was assessed by Cochrane's method. Heterogeneity of pooled prevalence was calculated using the chi-square test on Cochrane's Q statistic, which was quantified by I-square values. The random-effects analyses of proportions were used to determine the pooled prevalence of DENV antibodies, antigen and RNA from eligible studies. Of these, 3 studies reported co-circulation of all the 4 serotypes, while 2 separately reported co-circulation of DENV-1 &2 and DENV-1 to -3. All the antibody-based studies had significantly high heterogeneity (I2 >90%, P <0.05), while the NS1 and PCR-based studies had low heterogeneity (I2 <25%, P >0.05). The pooled prevalence of DENV IgM, IgG, RNA, NS1 and neutralizing antibodies were 16.8%, 34.7%, 7.7%, 7.7% and 0.7%, respectively. South-east Nigeria had the highest pooled DENV-IgG seropositivity, 77.1%. Marital status, gender, educational level and occupation status, the proximity of residence to refuse dumpsite, frequent use of trousers and long sleeve shirts were significantly associated with DENV IgG seropositivity (P <0.05). Based on these findings, it can be inferred that Nigeria is hyperendemic for Dengue fever and needs concerted efforts to control its spread within and outside the country.