Predictors of Self-repackaging of Antiretroviral Therapy in Northern Tanzania.
Predictors of Self-repackaging of Antiretroviral Therapy in Northern Tanzania.
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坦桑尼亚北部抗逆转录病毒疗法自我重新包装的预测因素。
DOI：
10.5993/ajhb.46.2.3
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发表时间：
2022-04-20
影响因子：
2.3
通讯作者：
Ramadhani, Habib O.
中科院分区：
文献类型：
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作者：
Semvua, Seleman Khamis;Kim, Christine Yaeree;Muiruri, Charles;Peter, Timothy Antipas;Mmbaga, Blandina T.;Bartlett, John A.;Zullig, Leah L.;Jazowski, Shelley A.;Knettel, Brandon A.;Karia, Francis P.;Ramadhani, Habib O.
在这项研究中，我们探讨了坦桑尼亚北方艾滋病毒感染者（PLHIV）中“研究人员观察”的患者启动的抗逆转录病毒治疗（ART）重新包装做法的决定因素。我们使用了准实验设计来描述ART自我重新包装的流行程度;我们进行了面对面的调查，以确定与ART自我重新包装实践相关的因素。数据收集地点包括基利曼哈罗基督教医疗中心和马文齐转诊医院。我们使用分配给ART包装的研究特定数字标识符来确定自我重新包装行为。自我重新包装被定义为一个二元变量，其中在至少2次诊所访视中丢弃抗逆转录病毒药物包装的参与者被归类为自我重新包装者。我们使用多变量逻辑回归来评估患者主动重新包装的决定因素。在590名研究参与者中，57.6%的人根据研究人员的观察进行自我重新包装，55.6%的人根据患者的报告进行自我重新包装。研究人员观察到的自我重新包装与性别（AOR = 1.590; 95%CI：1.011，2.502），就业状况（AOR = 0.475：95%CI; 0.239，0.942）和研究地点（AOR = 0.218; 95%CI：0.134，0.355）相关。很大一部分患者出于各种原因自行重新包装其ART。卫生系统的干预措施应侧重于解决男子和失业患者重新包装的属性。
In this study, we explored determinants of “researcher-observed” patient-initiated antiretroviral therapy (ART) repackaging practices among people living with HIV (PLHIV) in Northern Tanzania. We used a quasi-experimental design to describe the prevalence of ART self-repackaging; we conducted face-to-face surveys to determine factors associated with ART self-repackaging practices. Data collection sites included the Kilimanjaro Christian Medical Centre and the Mawenzi Referral Hospital. We used study-specific numerical identifiers assigned to ARTs packaging to determine self-repackaging behavior. Self-repackaging was defined as a binary variable where participants who discarded antiretroviral drugs packaging in at least 2 clinic visits were classified as self-repackagers. We used multivariable logistic regression to assess the determinants of patient-initiated repackaging practices. Among 590 study participants, 57.6% self-repackaged based on researcher observation and 55.6% self-repackaged based on patient report. Researcher-observed self-repackaging was associated with gender (AOR = 1.590; 95% CI: 1.011, 2.502), employment status (AOR = 0.475: 95% CI; 0.239, 0.942), and study site (AOR = 0.218; 95% CI: 0.134, 0.355). A substantial proportion of patients self-repackage their ARTs for various reasons. Health system interventions should focus on addressing the attributes of repackaging among men and unemployed patients.