ENDOCRINE-INDUCED REGRESSION OF CANCERS
ENDOCRINE-INDUCED REGRESSION OF CANCERS
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DOI：
10.1126/science.156.3778.1050
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发表时间：
1967-01-01
期刊：
影响因子：
56.9
通讯作者：
HUGGINS, C
中科院分区：
文献类型：
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作者：
HUGGINS, C
癌症不是自主的，本质上是自我延续的。它的生长可以通过激素的作用来维持和繁殖。激素或诱导生理效应的合成物质对人类和动物几种激素反应性癌症的生存具有至关重要的意义。相反类型的激素状态变化可以引起退化，在某些情况下，可以治愈这类癌症。这些修饰是通过给予大量的关键化合物来剥夺基本激素和干扰激素。通过内分泌方法控制癌症可以描述如下：某些类型的癌细胞在对激素环境变化的反应中与它们产生的细胞不同；某些癌症依赖于激素，当支持激素被消除时就会死亡；当使用大量激素时，某些癌症就会死亡。
Cancer is not autonomous and intrinsically self-prepetuating. Its growth can be sustained and propagated by hormonal function. Hormones, or synthetic substances inducing physiologic effects are of crucial significance for survival of several kinds of hormone-responsive cancers in man and animals. Opposite sorts of change of the hormonal status can induce regression and, in some instances, cure such cancers. These modifications are deprivation of essential hormones and hormone interference by giving large amounts of critical compounds. The control of cancer by endocrine methods can be described as follows: some types of cancer cells differ from the cells from which they arose in their response to change in their hormonal environment; certain cancers arehorm one -dependent and die when supporting hormones are eliminated; certain cancers succumb when large amounts of hormones are administered.