Molecular studies of the parental origin and nature of human X isochromosomes.
Molecular studies of the parental origin and nature of human X isochromosomes.
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人类 X 等染色体的亲本起源和性质的分子研究。
DOI：
10.1159/000132553
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发表时间：
1988
期刊：
影响因子：
--
通讯作者：
Jacobs,PA
中科院分区：
文献类型：
--
作者：
Harbison,M;Hassold,T;Kobryn,C;Jacobs,PA
用x染色体限制性片段长度多态性测定了9个具有i（Xq）或idic（Xq）的同工染色体的亲本来源。我们能够确定9条同工染色体中8条的亲本来源，其中6条来自母亲，2条来自父亲。在两个案例中，一个i（Xq）和一个idiq (Xq)，我们使用Xq标记来确定同工染色体的杂合性水平。在所有被测试的位点上，它们都是纯合的，这表明它们都起源于单个X染色体，而不是两个X染色体之间的物质交换。
X-chromosome restriction fragment length polymorphisms were used to determine the parental origin of the isochromosome in nine individuals with an i(Xq) or idic(Xq). We were able to specify the parental source of eight of the nine isochromosomes, with six being maternal and two paternal in origin. In two cases, one i(Xq) and one idic(Xq), we used Xq markers to determine the level of heterozygosity in the isochromosome. Each was homozygous at all tested loci, suggesting that each originated from a single X chromosome and not from an exchange of material between two X’s.