GENETIC AND MATERNAL INFLUENCES ON SUSCEPTIBILITY TO SEIZURES - AN ANALYTIC REVIEW
GENETIC AND MATERNAL INFLUENCES ON SUSCEPTIBILITY TO SEIZURES - AN ANALYTIC REVIEW
复制标题
DOI：
10.1093/oxfordjournals.aje.a114197
复制
发表时间：
1985-01-01
影响因子：
5
通讯作者：
SUSSER, M
中科院分区：
文献类型：
--
作者：
OTTMAN, R;HAUSER, WA;SUSSER, M
癫痫发作的家族聚集性是公认的，但遗传因素在多大程度上解释这种家族聚集性仍不清楚。除了遗传因素外，受影响个体的亲属中癫痫发作疾病发病率增加的可能解释包括共同的行为模式和共同的环境暴露。遗传因素在癫痫发作障碍中的作用很难确定，部分原因是其临床和病因学的异质性。癫痫发作的表现从几乎看不见的意识丧失到全面的强直阵挛性发作。1格特鲁德·H.哥伦比亚大学医学院谢尔盖夫斯基中心，630 W。168街，纽约，NY 10032。（转载请求露丝·奥特兰博士在这个地址。
Familial aggregation of seizure disorders is well established, but the extent to which genetic factors explain this familial aggregation remains unclear. Possible explanations for increased incidence of seizure disorders among relatives of affected individuals include shared behavior patterns and common environmental exposures, in addition to genetic factors. The role of genetic factors in seizure disorders is difficult to determine, in part because of their clinical and etiologic heterogeneity. The manifestations of seizures range from barely visible lapses in consciousness to the full-blown tonic-clonicAbbreviation: RR, relative risk. 1 Gertrude H. Sergievsky Center, Faculty of Medicine, Columbia University, 630 W. 168th Street, New York, NY 10032.(Reprint requests to Dr. Ruth Ottraan at this address.)