An activating immunoreceptor complex formed by NKG2D and DAP10
An activating immunoreceptor complex formed by NKG2D and DAP10
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DOI：
10.1126/science.285.5428.730
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发表时间：
1999-07-30
期刊：
影响因子：
56.9
通讯作者：
Phillips, JH
中科院分区：
文献类型：
--
作者：
Wu, J;Song, YL;Phillips, JH
许多免疫受体由单独的配体结合亚基和信号转导亚基组成。在自然杀伤细胞（NK）和T细胞中，DAP10被鉴定为与NKG2D（应激诱导和肿瘤相关的主要组织相容性复合体分子MICA的受体）激活受体复合体中的细胞表面衔接蛋白。在DAP10细胞质域中，Src同源性2 （SH2）结构域结合位点能够募集磷脂酰肌醇3-激酶（PI 3-激酶）的p85亚基，提供依赖nkg2d的信号转导。因此，NKG2D-DAP10受体复合物可能激活NK和T细胞对mica肿瘤的反应。
Many immune receptors are composed of separate Ligand-binding and signal-transducing subunits. In natural killer (NK) and T cells, DAP10 was identified as a cell surface adaptor protein in an activating receptor complex with NKG2D, a receptor for the stress-inducible and tumor-associated major histocompatibility complex molecule MICA. Within the DAP10 cytoplasmic domain, an Src homology 2 (SH2) domain-binding site was capable of recruiting the p85 subunit of the phosphatidylinositol 3-kinase (PI 3-kinase), providing for NKG2D-dependent signal transduction. Thus, NKG2D-DAP10 receptor complexes may activate NK and T cell responses against MICA-bearing tumors.