Estimates of the burden of malaria morbidity in Africa in children under the age of 5 years
Estimates of the burden of malaria morbidity in Africa in children under the age of 5 years
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DOI：
10.1111/j.1365-3156.2008.02076.x
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发表时间：
2008-06-01
影响因子：
3.3
通讯作者：
Schellenberg, Joanna R. M. Armstrong
中科院分区：
文献类型：
--
作者：
Roca-Feltrer, Arantxa;Carneiro, Ilona;Schellenberg, Joanna R. M. Armstrong
OBJECTIVE To estimate the direct burden of malaria among children younger than 5 years in sub-Saharan Africa (SSA) for the year 2000, as part of a wider initiative on burden estimates.METHODS A systematic literature review was undertaken in June 2003. Severe malaria outcomes (cerebral malaria, severe malarial anaemia and respiratory distress) and non-severe malaria data were abstracted separately, together with information on the characteristics of each study and its population. Population characteristics were also collated at a national level. A meta-regression model was used to predict the incidence of malaria fevers at a national level. For severe outcomes, results were presented as median rates as data were too sparse for modelling.RESULTS For the year 2000, an estimated 545 000 (uncertainty interval: 105 000-1 750 000) children under the age of 5 in SSA experienced an episode of severe malaria for which they were admitted to hospital. A total of 24 000 (interquartile range: 12 000-37 000) suffered from persistent neurological deficits as a result of cerebral malaria. The number of malaria fevers associated with high parasite density in under-5s in SSA in 2000 was estimated as 115 750 000 (uncertainty interval: 91 243 000-257 957 000).CONCLUSION Our study predicts a lower burden than previous estimates of under-5 malaria morbidity in SSA. As there is a lack of suitable data to enable comprehensive estimates of annual malaria incidence, we describe the information needed to improve the validity of future estimates.
