Catechol O-methyltransferase Val158Met polymorphism is associated with cognitive performance in nondemented adults
Catechol O-methyltransferase Val158Met polymorphism is associated with cognitive performance in nondemented adults
复制标题
DOI：
10.1162/0898929054475136
复制
发表时间：
2005-07-01
影响因子：
3.2
通讯作者：
Nilsson, LR
中科院分区：
文献类型：
--
作者：
de Frias, CM;Annerbrink, K;Nilsson, LR
儿茶酚 O-甲基转移酶 (COMT) 基因对于前额皮质多巴胺的代谢降解至关重要。在本研究中，我们研究了 COMT 基因中 Val 158 Met 多态性对成年和老年个体差异和认知（执行功能和视觉空间能力）变化的影响。参与者是 292 名非痴呆男性（最初年龄为 35-85 岁），他们是从人群中随机抽取的样本（即 Betula 研究），以 5 年的间隔进行了两次测试。验证性因素分析用于测试执行功能的三个指标（言语流畅性、工作记忆和汉诺塔）的基本结构。使用重复测量方差分析来检查 COMT、年龄、执行功能和视觉空间（块设计）任务之间的关联。与 Met/Met 基因型携带者（酶活性较低）相比，Val 等位基因携带者（酶活性较高）在执行功能和视觉空间任务方面表现较差。具有 Val/Val 基因型的个体的执行功能在 5 年期间下降，而 Met 等位基因携带者的执行功能保持稳定。视觉空间能力的年龄 x COMT 交互作用仅对中年男性产生影响。 COMT 多态性是非痴呆中老年人执行功能和流体智力的候选基因。
The catechol O-methyltransferase ( COMT) gene is essential in the metabolic degradation of dopamine in the prefrontal cortex. In the present study, we examined the effect of a Val 158 Met polymorphism in the COMT gene on individual differences and changes in cognition ( executive functions and visuospatial ability) in adulthood and old age. The participants were 292 nondemented men ( initially aged 35-85 years) from a random sample of the population (i.e., the Betula study) tested at two occasions with a 5-year interval. Confirmatory factor analyses were used to test the underlying structure of three indicators of executive functions ( verbal fluency, working memory, and Tower of Hanoi). Associations between COMT, age, executive functioning, and visuospatial ( block design) tasks were examined using repeated-measures analyses of variance. Carriers of the Val allele ( with higher enzyme activity) compared with carriers of the Met/Met genotype ( with low enzyme activity) performed worse on executive functioning and visuospatial tasks. Individuals with the Val/Val genotype declined in executive functioning over the 5-year period, whereas carriers of the Met allele remained stable in performance. An Age x COMT interaction for visuospatial ability located the effect for middle-aged men only. This COMT polymorphism is a plausible candidate gene for executive functioning and fluid intelligence in nondemented middle-aged and older adults.