Characterization of viral dynamics in human immunodeficiency virus type 1-infected patients treated with combination antiretroviral therapy: Relationships to host factors, cellular restoration, and virologic end points
Characterization of viral dynamics in human immunodeficiency virus type 1-infected patients treated with combination antiretroviral therapy: Relationships to host factors, cellular restoration, and virologic end points
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DOI：
10.1086/314670
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发表时间：
1999-04-01
影响因子：
6.4
通讯作者：
Lederman, MM
中科院分区：
文献类型：
--
作者：
Wu, HL;Kuritzkes, DR;Lederman, MM
在48例接受利托那韦、齐多夫定和拉米夫定治疗的患者中建立了双相血浆病毒衰减模型，估计的第一和第二相衰减率为d（1）为0.47/天，d（2）为0.04/天。两种衰减率的患者间差异是显着的。d（1）与基线CD 4（+）、CD 4（+）CD 28（+）和CD 8（+）CD 28（+）T淋巴细胞计数直接相关（P
Biphasic plasma viral decays were modeled in 48 patients treated with ritonavir, zidovudine, and lamivudine, Estimated first- and second-phase decay rates were d(1) as 0.47/day and d(2) as 0.04/day. Interpatient differences in both decay rates were significant. The d(1) was directly correlated with baseline CD4(+), CD4(+)CD28(+), and CD8(+)CD28(+) T lymphocyte counts (P