The fungal pattern recognition receptor, Dectin-1, and the associated cluster of C-type lectin-like receptors.
The fungal pattern recognition receptor, Dectin-1, and the associated cluster of C-type lectin-like receptors.
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DOI：
10.1111/j.1574-6968.2008.01418.x
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发表时间：
2009-01
影响因子：
2.1
通讯作者：
Brown GD
中科院分区：
文献类型：
--
作者：
Huysamen C;Brown GD
哺乳动物自然杀伤基因复合体（NKC）包含几个II型跨膜c型凝集素样受体（CLRs）家族，这些受体通过识别内源性（或自身）蛋白质配体参与病毒感染或转化细胞的检测。然而，NKC中的某些CLR家族，特别是由髓细胞表达的CLR家族，识别结构上不同的配体，并执行各种其他免疫和稳态功能。其中一个家族是clr的“Dectin-1簇”，包括MICL、CLEC-2、clec - 12b、clec - 9a、CLEC-1、Dectin-1和LOX-1。在这里，我们回顾了这些clr，探讨了我们目前对它们的配体和功能的理解，并强调了它们为免疫和体内平衡的潜在机制提供了新的见解。
The mammalian natural killer gene complex (NKC) contains several families of type II transmembrane C-type lectin-like receptors (CLRs) that are best known for their involvement in the detection of virally infected or transformed cells, through the recognition of endogenous (or self) proteinacious ligands. However, certain CLR families within the NKC, particularly those expressed by myeloid cells, recognize structurally diverse ligands and perform a variety of other immune and homoeostatic functions. One such family is the ‘Dectin-1 cluster’ of CLRs, which includes MICL, CLEC-2, CLEC12B, CLEC9A, CLEC-1, Dectin-1 and LOX-1. Here, we review each of these CLRs, exploring our current understanding of their ligands and functions and highlighting where they have provided new insights into the underlying mechanisms of immunity and homeostasis.
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DOI：
10.1042/bj20071216
发表时间：
2008-04-01
期刊：
The Biochemical journal
影响因子：
--
作者：
Christou CM;Pearce AC;Watson AA;Mistry AR;Pollitt AY;Fenton-May AE;Johnson LA;Jackson DG;Watson SP;O'Callaghan CA
通讯作者：
O'Callaghan CA
影响因子：
20.3
作者：
Han, YM;Zhang, MH;Cao, XT
通讯作者：
Cao, XT
影响因子：
5
作者：
Jimenez-A, M. del Pilar;Viriyakosol, S.;Fierer, J.
通讯作者：
Fierer, J.
影响因子：
5.4
作者：
Chaipan, Chawaree;Soilleux, Elizabeth J.;Poehlmann, Stefan
通讯作者：
Poehlmann, Stefan
影响因子：
64.8
作者：
Gross, Olaf;Gewies, Andreas;Ruland, Juergen
通讯作者：
Ruland, Juergen