Sleep transforms the cerebral trace of declarative memories
Sleep transforms the cerebral trace of declarative memories
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DOI：
10.1073/pnas.0705454104
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发表时间：
2007-11-20
影响因子：
11.1
通讯作者：
Peigneux, Philippe
中科院分区：
文献类型：
--
作者：
Gais, Steffen;Albouy, Genevieve;Peigneux, Philippe
在编码之后，记忆痕迹最初是脆弱的，必须得到加强才能成为永久性的。这个过程的初始步骤在细胞水平上发生在几分钟或几小时内。除了这种快速的突触整合，系统整合发生在几天到几年的时间范围内。对于陈述性记忆，后者被认为依赖于不同大脑区域之间的相互作用，特别是海马和内侧前额叶皮层（mPFC）。具体来说，睡眠被提议提供一种支持这种系统整合过程的环境，导致记忆的转移和可能的转化。使用功能磁共振成像，我们发现，学习后睡眠增强海马反应，在回忆学习后48小时的单词对，表明海马内的记忆在睡眠过程中的处理。同时，睡眠诱导海马和mPFC之间的记忆相关功能连接。在学习六个月后，当记忆在睡眠前被编码时，mPFC会被更强烈地激活，这表明睡眠会导致系统层面上记忆表征的长期变化。
After encoding, memory traces are initially fragile and have to be reinforced to become permanent. The initial steps of this process occur at a cellular level within minutes or hours. Besides this rapid synaptic consolidation, systems consolidation occurs within a time frame of days to years. For declarative memory, the latter is presumed to rely on an interaction between different brain regions, in particular the hippocampus and the medial prefrontal cortex (mPFC). Specifically, sleep has been proposed to provide a setting that supports such systems consolidation processes, leading to a transfer and perhaps transformation of memories. Using functional MRI, we show that postlearning sleep enhances hippocampal responses during recall of word pairs 48 h after learning, indicating intrahippocampal memory processing during sleep. At the same time, sleep induces a memory-related functional connectivity between the hippocampus and the mPFC. Six months after learning, memories activated the mPFC more strongly when they were encoded before sleep, showing that sleep leads to long-lasting changes in the representation of memories on a systems level.