SIMIAN VIRUS-40-ASSOCIATED FATAL INTERSTITIAL PNEUMONIA AND RENAL TUBULAR NECROSIS IN A RHESUS-MONKEY
SIMIAN VIRUS-40-ASSOCIATED FATAL INTERSTITIAL PNEUMONIA AND RENAL TUBULAR NECROSIS IN A RHESUS-MONKEY
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DOI：
10.1093/infdis/142.4.618
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发表时间：
1980-01-01
影响因子：
6.4
通讯作者：
KALTER, SS
中科院分区：
文献类型：
--
作者：
SHEFFIELD, WD;STRANDBERG, JD;KALTER, SS
SV 40分离自死于自然获得性间质性肺炎和肾小管坏死的年轻成年恒河猴。光镜检查显示嗜碱性核内包涵体与肺和肾的病变有关。这些夹杂物阳性的SV40抗原的免疫过氧化物酶染色的石蜡切片的受影响的器官。EM显示这些组织中的特征性乳多空病毒颗粒。本研究是第一次报道SV40在其自然宿主中可能引起肺和肾脏疾病。
SV40 was isolated from a young adult rhesus monkey dying of naturally acquired interstitial pneumonia and renal tubular necrosis. Light microscopic examination demonstrated basophilic intranuclear inclusions associated with the lesions in the lung and kidney. These inclusions were positive for SV40 antigen by immunoperoxidase staining of paraffin sections of affected organs. EM revealed characteristic papovavirus particles in these tissues. This study is the 1st report indicating that SV40 may produce pulmonary and renal disease in its natural host.