Quantitative microvascular analysis of retinal venous occlusions by spectral domain optical coherence tomography angiography.
Quantitative microvascular analysis of retinal venous occlusions by spectral domain optical coherence tomography angiography.
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DOI：
10.1371/journal.pone.0176404
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发表时间：
2017
期刊：
影响因子：
3.7
通讯作者：
Kashani AH
中科院分区：
文献类型：
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作者：
Koulisis N;Kim AY;Chu Z;Shahidzadeh A;Burkemper B;Olmos de Koo LC;Moshfeghi AA;Ameri H;Puliafito CA;Isozaki VL;Wang RK;Kashani AH
利用光学相干断层扫描血管造影（OCTA）定量评估视网膜静脉闭塞（RVO）患者的视网膜微血管。回顾性、横断面、观察性病例系列。纳入60名受试者（84只眼）（20只BRVO， 14只CRVO， 24只未受影响的同伴眼和26只对照）。在3x3mm黄斑中央区域的光谱域-OCTA系统原型上进行OCTA。使用定制软件对视网膜毛细血管的形态和密度进行量化，采用四个定量参数。对分节视网膜层和非分节全视网膜的血管系统进行了分析。分形维数（FD）、血管密度（VD）、骨骼密度（SD）和血管直径指数（VDI）在分节视网膜层和非分节的全视网膜血管。非分割分析显示，与对照组相比，RVO眼睛的FD（1.64±0.01 vs 1.715±0.002,p<0.001）、VD（0.32±0.01 vs 0.432±0.002,p<0.001）和SD（0.073±0.004 vs 0.099±0.001,p<0.001）显著降低。与同侧眼比较，FD、VD、SD较低（p<0.001）， VDI较高（p<0.001）。FD、VD和SD随着RVO程度（或类型）的增加而逐渐降低（对照vs BRVO vs CRVO； p<0.001）。在未受影响的眼中，FD、VD和SD与对照眼或受影响的RVO眼相比有显著差异（p<0.001）。定量OCTA显示，与对照组或未受影响的眼睛相比，BRVO和CRVO受试者在所有血管层的毛细血管密度和形态上存在显著差异。与对照组相比，未受影响的眼睛也表现出显著差异。OCTA可以对rvo相关微血管变化进行无创、分层、定量评估。
To quantitatively evaluate the retinal microvasculature in human subjects with retinal venous occlusions (RVO) using optical coherence tomography angiography (OCTA). Retrospective, cross-sectional, observational case series. Sixty subjects (84 eyes) were included (20 BRVO, 14 CRVO, 24 unaffected fellow eyes, and 26 controls). OCTA was performed on a prototype, spectral domain-OCTA system in the 3x3mm central macular region. Custom software was used to quantify morphology and density of retinal capillaries using four quantitative parameters. The vasculature of the segmented retinal layers and nonsegmented whole retina were analyzed. Fractal dimension (FD), vessel density (VD), skeletal density (SD), and vessel diameter index (VDI) within the segmented retinal layers and nonsegmented whole retina vasculature. Nonsegmented analysis of RVO eyes demonstrated significantly lower FD (1.64±0.01 vs 1.715±0.002; p<0.001), VD (0.32±0.01 vs 0.432±0.002; p<0.001), and SD (0.073±0.004 vs 0.099±0.001; p<0.001) compared to controls. Compared to the fellow eye, FD, VD and SD were lower (p<0.001), and VDI was higher (p<0.001). FD, VD, and SD progressively decreased as the extent (or type) of RVO increased (control vs BRVO vs CRVO; p<0.001). In the unaffected fellow eye FD, VD and SD showed significant differences when compared to control eyes or affected RVO eyes (p<0.001). Quantitative OCTA of the central 3x3mm macular region demonstrates significant differences in capillary density and morphology among subjects with BRVO and CRVO compared to controls or unaffected fellow eyes in all vascular layers. The unaffected fellow eyes also demonstrate significant differences when compared to controls. OCTA allows for noninvasive, layer-specific, quantitative evaluation of RVO-associated microvascular changes.