Combination therapy with amphotericin B lipid complex and caspofungin acetate of disseminated zygomycosis in diabetic ketoacidotic mice
Combination therapy with amphotericin B lipid complex and caspofungin acetate of disseminated zygomycosis in diabetic ketoacidotic mice
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DOI：
10.1128/aac.49.2.830-832.2005
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发表时间：
2005-02-01
影响因子：
4.9
通讯作者：
Ibrahim, AS
中科院分区：
文献类型：
--
作者：
Spellberg, B;Fu, Y;Ibrahim, AS
我们研究了两性霉素B脂质复合体(ABLC)与卡泊芬净联合治疗米根霉播散性小鼠的效果。与接受单一治疗的小鼠和未接受治疗的对照组相比，联合治疗提高了小鼠的存活率(P<；0.05)，但不能改善器官清除。此外，预防性联合治疗并不比单纯预防性ABLC更有效。
We studied the combination of amphotericin B lipid complex (ABLC) and caspofungin in mice with disseminated Rhizopus oryzae. Combination therapy improved survival compared to that of mice given monotherapy and that of untreated controls (P < 0.05) but did not improve organ clearance. In addition, prophylactic combination therapy was not more effective than prophylactic ABLC alone.