Age-related changes in the human femoral cortex.
Age-related changes in the human femoral cortex.
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人类股骨皮质与年龄相关的变化。
DOI：
10.1002/jor.1100090202
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发表时间：
1991
期刊：
影响因子：
--
通讯作者：
Grynpas,MD
中科院分区：
文献类型：
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作者：
SimmonsJr,ED;Pritzker,KP;Grynpas,MD
随着年龄的增长，骨骼经历了结构的变化，但质变的性质仍有待确定。股骨中段标本取自四个不同年龄段的男性：20-25岁、40-45岁、60-65岁和80-85岁。每个股骨样本都通过密度分馏进行分析，这是一种允许根据矿化程度和成熟度分离骨骼的技术。20~25岁组以低密度骨为主。40-45岁组的特点是矿化程度更高，骨矿含量增加了2.1-2.2克/毫升。在60-65岁，低密度部分增加，表明新骨形成增加。在80-85岁时，密度最高的骨(2.2-2.3g/cc)增加，这可能代表未通过重塑过程正确去除的间质骨区域。化学研究没有发现Ca、P、Ca+PO4或Ca/P摩尔比随年龄的变化。X射线衍射研究表明，磷灰石的晶体尺寸没有随年龄或矿化程度的变化而变化。形态学研究证明，在老年组中，重塑活动和骨内小梁化增加，以及皮质内孔隙率增加。随着年龄的增长，最高密度分数的增加可能代表着较难重塑的骨矿物质池，这可能是间质骨。
Bone undergoes structural changes with aging, but the nature of qualitative changes remains to be established. Blocks of midshaft femur were taken at autopsy from men of four different age groups: 20–25 years, 40–45 years, 60–65 years, and 80–85 years. Each femoral specimen was analyzed by density fractionation, a technique that allows the separation of bone by extent of mineralization and maturity. In the 20–25 group, lower density bone predominates. The 40–45 group is characterized by more highly mineralized bone with an increase in the 2.1–2.2 g/cc fraction. At 60–65 years, an increase in the lower density fraction was found, indicating an increase in new bone formation. At 80–85 years, there is an increase in the highest density bone (2.2–2.3 g/cc), which may represent regions of interstitial bone not properly removed through remodeling processes. Chemical studies did not reveal any change in Ca, P, Ca + PO4, or Ca/P molar ratio with respect to age. X‐ray diffraction studies show no changes in apatite crystal size with respect to age or degree of mineralization. Morphological studies documented increased remodeling activity and endosteal trabecularization in the older age groups, as well as increased intracortical porosity. An increase in the highest density fraction with aging may represent a pool of bone mineral that is less accessible to remodeling, which may be the interstitial bone.