A fresh look at zebrafish from the perspective of cancer research.
A fresh look at zebrafish from the perspective of cancer research.
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从癌症研究的角度重新审视斑马鱼
DOI：
10.1186/s13046-015-0196-8
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发表时间：
2015-08-12
期刊：
影响因子：
--
通讯作者：
Ye J
中科院分区：
文献类型：
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作者：
Zhao S;Huang J;Ye J
斑马鱼代表了一种脊椎动物模式生物，在过去十年中已被广泛且越来越多地用于发育过程、伤口愈合、微生物-宿主相互作用和药物筛选的研究。随着斑马鱼在实验室中使用的增加，几个优点，如与人类的高度遗传同源性和透明的胚胎，可以明确的疾病评估，大大拓宽了其作为研究体内肿瘤发展的模型的用途。斑马鱼已被应用于癌症研究的多个领域，主要在以下领域：（1）通过致癌化学品、遗传技术和异种移植建立癌症模型;（2）评价肿瘤血管生成;（3）研究肿瘤转移;和（4）抗肿瘤药物筛选和药物毒性评价。在这项研究中，我们提供了一个全面的概述斑马鱼的作用，以强调在癌症研究中使用它们作为模式生物的优势。并回顾了几个相关的成功事件。
Zebrafish represent a vertebrate model organism that has been widely, and increasingly, employed over the last decade in the study of developmental processes, wound healing, microbe-host interactions, and drug screening. With the increase in the laboratory use of zebrafish, several advantages, such as a high genetic homology to humans and transparent embryos, which allow clear disease evaluation, have greatly widened its use as a model for studying tumor development in vivo. The use of zebrafish has been applied in several areas of cancer research, mainly in the following domains: (1) establishing cancer models by carcinogenic chemical, genetic technology, and xenotransplantation; (2) evaluating tumor angiogenesis; (3) studying tumor metastasis; and (4) anti-tumor drug screening and drug toxicity evaluation. In this study, we provide a comprehensive overview of the role of zebrafish in order to underline the advantages of using them as a model organism in cancer research. Several related successful events are also reviewed.