Stimulus-driven competition in a cholinergic midbrain nucleus.

Stimulus-driven competition in a cholinergic midbrain nucleus.
复制标题

DOI:
10.1038/nn.2573
复制
发表时间:
2010-07
影响因子:
25
通讯作者:
Knudsen, Eric I.
Knudsen, Eric I.
中科院分区:
医学1区
文献类型:
--
作者:
Asadollahi, Ali;Mysore, Shreesh P.;Knudsen, Eric I.

文献摘要

参考文献

被引文献

相似文献

大脑选择特定刺激作为下一个凝视目标的机制尚不清楚。猫头鹰中脑中的胆碱能核显示出其在自下而上的刺激选择中所起的作用。isthmi parvoculularis (Ipc)核中的神经元对广泛的视觉和听觉特征做出反应,但它们不会对这些特征的特定值进行调整。相反,它们对整个空间中刺激的相对强度进行编码。许多神经元表现出类似开关的特性,当一个刺激成为最强的刺激时,它们的感受野会突然增加对刺激的反应。这种信息以周期性(25-50赫兹)的胆碱能活动爆发的形式直接传播到视觉顶盖,这是一种涉及凝视控制和刺激选择的结构。Ipc神经元的功能特性类似于“显著性地图”,这是空间注意力和凝视控制计算模型的核心组成部分。
The mechanisms by which the brain selects a particular stimulus as the next target for gaze are poorly understood. A cholinergic nucleus in the owl’s midbrain exhibits functional properties that suggest its role in bottom-up stimulus selection. Neurons in the nucleus isthmi pars parvocellularis (Ipc) respond to wide ranges of visual and auditory features, but they are not tuned to particular values of those features. Instead, they encode the relative strengths of stimuli across the entirety of space. Many neurons exhibit switch-like properties, abruptly increasing their responses to a stimulus in their receptive field when it becomes the strongest stimulus. This information propagates directly to the optic tectum, a structure involved in gaze control and stimulus selection, as periodic (25–50 Hz) bursts of cholinergic activity. The functional properties of Ipc neurons resemble those of a “salience map”, a core component in computational models for spatial attention and gaze control.
DOI: 10.1038/nn1391
发表时间: 2005-02-01
影响因子: 25
作者:
Mariño, J;Schummers, J;Sur, M
通讯作者: Sur, M
DOI: 10.1523/jneurosci.3946-06.2006
发表时间: 2006-12-06
影响因子: 5.3
作者:
Maczko, Kristin A.;Knudsen, Phyllis F.;Knudsen, Eric I.
通讯作者: Knudsen, Eric I.
DOI: 10.1152/jn.1974.37.6.1262
发表时间: 1974-01-01
影响因子: 2.5
作者:
RIZZOLATTI, G;CAMARDA, R;PISA, M
通讯作者: PISA, M
DOI: 10.1126/science.1138071
发表时间: 2007-03-30
期刊: SCIENCE
影响因子: 56.9
作者:
Buschman, Timothy J.;Miller, Earl K.
通讯作者: Miller, Earl K.
DOI: 10.1152/jn.00211.2005
发表时间: 2005-12-01
影响因子: 2.5
作者:
Endo, T;Yanagawa, Y;Isa, T
通讯作者: Isa, T