Resident viruses and their interactions with the immune system.
Resident viruses and their interactions with the immune system.
复制标题
驻留病毒及其与免疫系统的相互作用。
作者：
人体内定植有包括病毒在内的多种常驻微生物群落。最近对宏基因组的研究已经开始表征人类“病毒生物群”及其相关基因（“病毒组”）的组成，并促进了宿主-病毒生物群相互作用的新兴领域。在这个角度来看，我们探讨如何与免疫系统的居民病毒相互作用。我们回顾了最近的研究结果，强调了免疫系统在塑造病毒生物群组成中的作用，并考虑了常驻病毒如何影响宿主免疫力。最后，我们讨论了对人类健康的病毒生物群免疫系统的相互作用的影响。
The human body is colonized with a diverse resident microflora that includes viruses. Recent studies of metagenomes have begun to characterize the composition of the human 'virobiota' and its associated genes (the 'virome'), and have fostered the emerging field of host-virobiota interactions. In this Perspective, we explore how resident viruses interact with the immune system. We review recent findings that highlight the role of the immune system in shaping the composition of the virobiota and consider how resident viruses may impact host immunity. Finally, we discuss the implications of virobiota–immune system interactions for human health.