AGING SKIN
AGING SKIN
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DOI：
10.1016/s0002-9343(99)80066-7
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发表时间：
1995-01-16
影响因子：
5.9
通讯作者：
BOLOGNIA, JL
中科院分区：
文献类型：
--
作者：
BOLOGNIA, JL
皮肤老化是光化性损伤、时间老化和激素影响的复合物。大多数与衰老相关的变化，如皱纹和日光性雀斑（“肝斑”），是由于光老化，反映了累积的阳光照射以及皮肤色素沉着。传统上，随时间老化包括发生在非阳光暴露区域（如臀部）的皮肤变化，并且在男性和女性中均观察到。一个临床例子是由于弹性纤维变性导致的软组织下垂。在女性中，关于激素对皮肤老化影响的研究集中在雌激素上;在男性中，关于睾丸激素影响的研究数量有限。后者显示了耻骨皮肤组织雄激素的年龄依赖性降低，但阴囊或大腿皮肤没有。迄今为止，年龄尚未显示对雄激素受体结合有影响，尽管已经描述了包皮5 α-还原酶活性随年龄增加而降低。在来自包皮的成纤维细胞培养物中，关于5 α-还原酶活性是否以年龄依赖性方式降低，存在相互矛盾的结果。一些被归类为继发于年龄老化的皮肤变化，如皮脂腺活动减少和毛发生长减少，实际上可能代表组织雄激素浓度随年龄增长而下降。雄激素对年龄相关的角质形成细胞和成纤维细胞功能变化的影响仍然是推测性的。
Aging of the skin is a composite of actinic damage, chronologic aging, and hormonal influences. The majority of changes associated with aging, such as wrinkles and solar lentigines (''liver spots''), are due to photoaging and reflect cumulative sun exposure as well as skin pigmentation. Classically, chronologic aging includes those cutaneous changes that occur in non-sun-exposed areas, such as the buttocks, and are observed in both men and women. A clinical example would be soft tissue sagging due to elastic fiber degeneration. In women, investigations into the effect of hormones on aging of the skin have concentrated on estrogens; in men, there have been a limited number of studies on the influence of testosterone. The latter have Shown an age-dependent decrease in tissue androgens in pubic skin, but not scrotal or thigh skin. To date, age has not been shown to have an effect on androgen receptor binding, although a decrease in foreskin 5 alpha-reductase activity with increasing age has been described. In fibroblast cultures from foreskins, there have been conflicting results as to whether 5 alpha-reductase activity decreases in an age-dependent manner. Some of the skin changes that have been categorized as secondary to chronologic aging, such as decreased sebaceous gland activity and decreased hair growth, may actually represent a decline in the concentration of tissue androgens with increasing age. The influence of androgens on age-related changes in keratinocyte and fibroblast function remains speculative.