Vulnerability to psychopathology in nicotine-dependent smokers: an epidemiologic study of young adults.
Vulnerability to psychopathology in nicotine-dependent smokers: an epidemiologic study of young adults.
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尼古丁依赖吸烟者对精神病理学的脆弱性：一项针对年轻人的流行病学研究。
DOI：
10.1176/ajp.150.6.941
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发表时间：
1993
期刊：
影响因子：
--
通讯作者：
Andreski,P
中科院分区：
文献类型：
--
作者：
Breslau,N;Kilbey,MM;Andreski,P
目的在之前的一篇文章中，作者报道了社区年轻人样本中尼古丁依赖与精神疾病之间的关系。在DSM-III-R尼古丁依赖人群中发现重度抑郁和焦虑障碍的终生发病率增加，而在非依赖吸烟者中没有发现。本研究的目的是研究尼古丁依赖与四种非精神病性精神疾病心理易感性的关系。方法随机选择1007名21- 30岁的大型健康维护组织成员，采用国家精神卫生研究所诊断访谈表（DSM-III-R版）进行访谈。获得神经质、消极情绪、绝望和一般情绪困扰的自我评定。结果尼古丁依赖，而非非依赖吸烟，与精神病理易感性的所有四项指标得分较高相关。除了一个例外，当当前吸烟状况、重度抑郁症或焦虑症史、酒精和药物使用障碍、种族和教育水平等变量被控制时，尼古丁依赖与这些心理测量之间的关联仍然显著；尼古丁依赖与一般情绪困扰的关系不显著。结论神经过敏症及其相关心理脆弱性易导致尼古丁依赖和重度抑郁或焦虑障碍。
ObjectiveIn a previous article the authors reported associations between nicotine dependence and psychiatric disorders in a community sample of young adults. Increased lifetime rates of major depression and anxiety disorders were found in persons with DSM-III-R nicotine dependence but not in nondependent smokers. The purpose of the present study was to examine the associations of nicotine dependence with four measures of psychologic vulnerability to nonpsychotic psychiatric disorders.MethodA randomly chosen group of 1,007 21-to 30-year-old members of a large health maintenance organization were interviewed with the National Institute of Mental Health Diagnostic Interview Schedule, revised for DSM-III-R diagnoses. Self-ratings of neuroticism, negative affect, hopelessness, and general emotional distress were obtained.ResultsNicotine dependence, but not nondependent smoking, was associated with higher scores on all four measures of vulnerability to psychopathology. With one exception the associations between nicotine dependence and these psychologic measures remained significant when the variables current smoking status, history of major depression or anxiety disorders, alcohol and drug use disorders, race, and level of education were controlled; the association of nicotine dependence with general emotional distress was not significant.ConclusionsNeuroticism and the correlated psychologic vulnerabilities may commonly predispose to nicotine dependence and major depression or anxiety disorders.