Osteoporosis and bone metabolism in postmenopausal women with osteoarthritis of the hand
Osteoporosis and bone metabolism in postmenopausal women with osteoarthritis of the hand
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DOI：
10.1097/01.gme.0000179048.08371.8e
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发表时间：
2006-05-01
影响因子：
2.7
通讯作者：
Ferraccioli, Glanfranco
中科院分区：
文献类型：
--
作者：
Zoli, Angelo;Lizzio, Marco M.;Ferraccioli, Glanfranco
目的：骨关节炎和骨质疏松症是影响绝经后妇女的两大健康问题。流行病学观察似乎表明骨关节炎和骨质疏松症之间可能存在反比关系。手的骨关节炎（EOA）是原发性骨关节炎的破坏性形式。本研究评价了女性手骨关节炎患者骨密度和骨代谢的变化，（平均年龄59岁，体重指数23 +/- 1.4 kg/m2），平均绝经9年，根据美国风湿病学会标准，患有手骨关节炎。15名女性显示手部EOA的临床和放射学证据。20名年龄、绝经年龄和体重指数相匹配的妇女组成对照组。使用双能X线吸收法测量髋关节和腰椎的骨密度（g/cm（2））。分析血清和尿钙和磷，血清25-羟维生素D，甲状旁腺激素，骨钙素和尿骨基质分解产物（CrossLaps）。结果：手部EOA妇女的T和Z评分L2-L4值显著低于非手部EOA妇女和对照组（P
Objective: Osteoarthritis and osteoporosis are two major health problems affecting postmenopausal women. Epidemiological observations seem to demonstrate a possible inverse relationship between osteoarthritis and osteoporosis. Erosive osteoarthritis (EOA) of the hand is a destructive form of primary osteoarthritis. This study evaluated bone mineral density and bone metabolism changes in erosive and nonerosive hand osteoarthritis women.Design: Fifty-five women (mean age, 59 years; body mass index, 23 +/- 1.4 kg/m(2)) who had been postmenopausal for an average of 9 years and who presented with hand osteoarthritis according to American College of Rheumatology criteria were enrolled in the study; 15 women showed clinical and radiological evidence of hand EOA. Twenty women matched for age, age at menopause, and body mass index formed the control group. Bone mineral density (g/cm(2)) was measured at the hip and lumbar spine using dual-energy x-ray absorptiometry. Serum and urinary calcium and phosphate, serum 25-hydroxyvitamin D, parathyroid hormone, osteocalcin, and urinary breakdown products of bone matrix (CrossLaps) were analyzed.Results: Women with hand EOA had a statistically significant lower T- and Z-score L2-L4 value than non-hand EOA women and controls (P