Usefulness as guided bone regeneration membrane of the alginate membrane.
Usefulness as guided bone regeneration membrane of the alginate membrane.
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DOI：
10.1016/s0142-9612(01)00332-5
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发表时间：
2002-05
期刊：
影响因子：
14
通讯作者：
Y. Ueyama;K. Ishikawa;T. Mano;T. Koyama;H. Nagatsuka;Kazuomi Suzuki;K. Ryoke
中科院分区：
文献类型：
--
作者：
Y. Ueyama;K. Ishikawa;T. Mano;T. Koyama;H. Nagatsuka;Kazuomi Suzuki;K. Ryoke
藻酸盐膜是一种新型的生物可吸收引导性骨再生膜，可直接置于骨缺损表面。其设计为将氯化钙水溶液滴入填充有海藻酸钠水溶液的骨缺损中。由于其与骨表面的紧密同化，藻酸盐膜是用于该手术的优秀试剂。本研究评价了藻酸盐膜在大鼠胫骨骨缺损中的短期生物相容性。还检查了GBR膜的可用性。因此，我们发现，与对照组相比，覆盖有藻酸盐膜的骨缺损的愈合过程延迟;然而，缺损恢复到几乎原始的状态。相反，在对照组中，由于结缔组织参与，骨缺损修复表现出分区。此外，我们观察到海藻酸钠浓度和海藻酸钠膜的吸收速率之间的关系。1.5%海藻酸钠膜的吸收缓慢。结果，这种化合物没有被完全吸收，骨修复就像沙漏一样。此外，藻酸盐膜周围不存在炎症反应。本研究结果表明，海藻酸盐膜有效地作为GBR膜。此外，由3%氯化钙和1%海藻酸钠组成的海藻酸钠膜最适合作为GBR膜。
Alginate membrane is a new bioabsorbable, guided bone regeneration (GBR) membrane, which is placed directly on the surface of the bone defect. It is designed to drop a calcium chloride aqueous solution into the bone defect, which is filled with sodium alginate aqueous solution. Alginate membrane is an excellent agent for this procedure due to its close assimilation to the surface of the bone. In this study, we evaluated the short-term biocompatibility of alginate membrane in the bone defects of rat tibiae. GBR membrane availability was also examined. Consequently, we found that the healing process in bone defects covered with an alginate membrane was delayed in comparison with that of controls; however, the defect was restored to nearly original condition. In contrast, in the controls, bone defect repairs exhibited partitioning as a result of connective tissue involvement. Furthermore, we observed a relation between the sodium alginate concentration and the rate of absorption of the sodium alginate membrane. Absorption of a 1.5% sodium alginate membrane was slow. As a result, the compound was not absorbed completely and bone repairs resembled an hourglass. Moreover, the inflammatory response was absent surrounding the alginate membrane. The present findings suggested that the alginate membrane functions effectively as a GBR membrane. In addition, the alginate membrane derived from 3% calcium chloride and 1% sodium alginate was most suitable as a GBR membrane.