Biosynthesis of Nanoparticles by Fungi: Large-Scale Production
Biosynthesis of Nanoparticles by Fungi: Large-Scale Production
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DOI：
10.1007/978-3-319-19456-1_8-1
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发表时间：
2017-01-01
期刊：
影响因子：
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通讯作者：
Vahabi, Khabat
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文献类型：
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作者：
Dorcheh, Sedigheh Karimi;Vahabi, Khabat
纳米粒子是纳米尺度的结构，在技术、工业、环境、医学和科学等各个领域有着广泛的应用。近年来，对NPs的需求不断增加，导致基于化学和物理方法开发其生产。这些做法本身对健康和环境不利。大规模生产NPs需要更安全的替代品，最终发展出环保方法。工业纳米生物技术利用生物可再生资源生产纳米材料。纳米材料生物合成的主要优点是减少能量摄入、减少温室气体排放和减少有害废物的产生。相比之下，其他合成方法对环境有不利影响。在纳米材料中，纳米颗粒因其广泛的应用而受到人们的关注。微生物，特别是细菌和真菌被用作生物制剂，并显示出纳米颗粒生物合成的良好潜力。在这里，我们强调了真菌工业生产NPs的不同方面，包括优点和缺点。此外，我们还讨论了真菌样蛋白质工程、代谢工程、合成生物学、系统生物学和下游加工等不同技术在大规模生产NPs方面的应用。
Nanoparticles are structures in nanoscale with a wide range of applications across various fields of technology, industry, environment, medicine, and science. Increasing demands for NPs caused to develop their production based on chemical and physical approaches, recently. These approaches carry health and environmental disadvantages with themselves. Need for safer alternatives in large-scale production of NPs ended up with development of eco-friendly methods. Industrial nanobiotechnology takes advantage of biological-based approaches to produce nanomaterial using biological renewable resources. Decreasing energy intake, greenhouse gas (GHG), and hazardous waste production are the main advantages of nanomaterial biosynthesis. In contrast, the other synthesis methods bring environmental drawbacks. Among the nanomaterials, nanoparticles have attracted the attention because of their wide spectrum of application. Microorganisms and in particular bacteria and fungi are used as the biological agents and showed a promising potential for biosynthesis of nanoparticles. Here we highlight different aspects of industrial production of NPs by fungi including advantages and disadvantages. Also, we discuss the application of different technologies in development of high-scale production of NPs by fungi-like protein engineering, metabolic engineering, synthetic biology, systems biology, and downstream processing.