Vascular targeting of nanoparticles for molecular imaging of diseased endothelium.
Vascular targeting of nanoparticles for molecular imaging of diseased endothelium.
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DOI：
10.1016/j.addr.2016.09.006
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发表时间：
2017-04
影响因子：
16.1
通讯作者：
Karathanasis E
中科院分区：
文献类型：
--
作者：
Atukorale PU;Covarrubias G;Bauer L;Karathanasis E
这篇综述旨在强调靶向纳米粒子在分子成像应用中的巨大潜力。作为最近的接触点，循环纳米颗粒可以直接接触到内皮上出现的疾病的靶向分子标记物。此外，由于在血管靶标上的几何增强的多价附着，纳米颗粒理想地适用于血管靶向。纳米颗粒、血管靶向和分子成像之间的这种天然协同作用可以为定量精确的疾病诊断和预后提供新的途径。除了靶向血管疾病的分子标记的明显应用（例如，动脉粥样硬化），深层组织疾病通常通过连续改变和重塑其邻近血管（例如，癌症）。因此，重塑的内皮为纳米颗粒和分子成像提供了广泛的靶点。为了证明分子成像的潜力，我们提出了各种纳米粒子设计用于癌症或动脉粥样硬化的分子成像，使用不同的成像方式。
This review seeks to highlight the enormous potential of targeted nanoparticles for molecular imaging applications. Being the closest point-of-contact, circulating nanoparticles can gain direct access to targetable molecular markers of disease that appear on the endothelium. Further, nanoparticles are ideally suitable to vascular targeting due to geometrically enhanced multivalent attachment on the vascular target. This natural synergy between nanoparticles, vascular targeting and molecular imaging can provide new avenues for diagnosis and prognosis of disease with quantitative precision. In addition to the obvious applications of targeting molecular signatures of vascular diseases (e.g., atherosclerosis), deep-tissue diseases often manifest themselves by continuously altering and remodeling their neighboring blood vessels (e.g., cancer). Thus, the remodeled endothelium provides a wide range of targets for nanoparticles and molecular imaging. To demonstrate the potential of molecular imaging, we present a variety of nanoparticles designed for molecular imaging of cancer or atherosclerosis using different imaging modalities.