Identifying patients at risk for late radiation-induced toxicity
Identifying patients at risk for late radiation-induced toxicity
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DOI：
10.1016/j.critrevonc.2010.08.003
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发表时间：
2012-12-01
影响因子：
6.2
通讯作者：
Ozsahin, M.
中科院分区：
文献类型：
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作者：
Azria, D.;Betz, M.;Ozsahin, M.
治疗性放射治疗的效果主要取决于目标体积内递送的总剂量。然而，输送到周围健康组织的剂量可能会降低许多治疗的治疗率。放疗期间和放疗后可能会出现两种不同的副作用（急性和晚期）。特别令人感兴趣的是辐射引起的晚期并发症（LC），因为其不可逆性以及对生活质量的潜在影响。在使用相同技术治疗的一组人群中，似乎明显存在个体放射敏感性。在这一研究领域涉及遗传的假设中，低 CD4 和 CD8 淋巴细胞凋亡被证明与高级别 LC 相关。此外，最近的数据表明，严重辐射诱导的LC患者的候选基因中具有4个或更多的单核苷酸多态性（SNP），并且体外辐射诱导的CD8淋巴细胞凋亡较低。正在进行的研究正在使用全基因组关联研究（GWAS）来分析整个基因组。 (C) 2010 Elsevier Ireland Ltd. 保留所有权利。
The impact of curative radiotherapy depends mainly on the total dose delivered in the targeted volume. Nevertheless, the dose delivered to the surrounding healthy tissues may reduce the therapeutic ratio of many treatments. Two different side effects (acute and late) can occur during and after radiotherapy. Of particular interest are the radiation-induced late complications (LC) due to their irreversibility and the potential impact on quality of life. In one population treated with the same technique, it appears that individual radiosensitivity clearly exists. In the hypothesis that genetic is involved in this area of research, low CD4 and CD8 lymphocyte apoptosis were shown to be correlated with high grade of LC. In addition, recent data suggest that patients with severe radiation-induced LC possess 4 or more single nucleotide polymorphisms (SNPs) in candidate genes and low radiation-induced CD8 lymphocyte apoptosis in vitro. On-going studies are being analyzing the entire genome using a genome-wide association study (GWAS). (C) 2010 Elsevier Ireland Ltd. All rights reserved.