Results from the 2nd Scientific Workshop of the ECCO (I): Impact of mucosal healing on the course of inflammatory bowel disease
Results from the 2nd Scientific Workshop of the ECCO (I): Impact of mucosal healing on the course of inflammatory bowel disease
复制标题
DOI：
10.1016/j.crohns.2011.06.009
复制
发表时间：
2011-10-01
影响因子：
8
通讯作者：
Sturm, Andreas
中科院分区：
文献类型：
--
作者：
Peyrin-Biroulet, Laurent;Ferrante, Marc;Sturm, Andreas
在过去的几年中，粘膜愈合已成为炎症性肠病临床试验的主要治疗目标。越来越多的证据表明，粘膜愈合可能会改变疾病的自然进程，减少手术的需要，降低溃疡性结肠炎和克罗恩病的住院率。粘膜愈合还可以防止长期疾病并发症的发展，例如克罗恩病中的肠损伤和溃疡性结肠炎中的结直肠癌。组织学愈合可能是溃疡性结肠炎的最终治疗目标，而其对克罗恩病病程的影响尚不清楚。在考虑停药之前，可能需要完全粘膜愈合。针对早期克罗恩病的治疗比针对长期疾病的粘膜愈合的方法更有效。有几个问题有待回答：粘膜愈合是否应该系统地应用于临床实践？我们是否应该优化治疗以实现粘膜愈合？改变疾病进程所需的肠道愈合程度是什么？需要针对这些问题进行大型前瞻性研究。(C)2011年欧洲克罗恩病和结肠炎组织。Elsevier B.V.出版，保留所有权利。
Over the past years, mucosal healing has emerged as a major therapeutic goal in clinical trials in inflammatory bowel diseases. Accumulating evidence indicates that mucosal healing may change the natural course of the disease by decreasing the need for surgery and reducing hospitalization rates in both ulcerative colitis and Crohn's disease. Mucosal healing may also prevent the development of long-term disease complications, such as bowel damage in Crohn's disease and colorectal cancer in ulcerative colitis. Histologic healing may be the ultimate therapeutic goal in ulcerative colitis, whereas its impact on the course of Crohn's disease is unknown. Complete mucosal healing may be required before considering drug withdrawal. Targeting early Crohn's disease is more effective than approaches aimed at healing mucosa in longstanding disease. Several questions remain to be answered: should mucosal healing be systematically used in clinical practice? Should we optimize therapies to achieve mucosal healing? What is the degree of intestinal healing that is required to change the disease course? Large prospective studies addressing these issues are needed. (C) 2011 European Crohn's and Colitis Organisation. Published by Elsevier B.V. All rights reserved.