Cognitive function and endogenous sex hormones in older women
Cognitive function and endogenous sex hormones in older women
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DOI：
10.1111/j.1532-5415.1999.tb07427.x
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发表时间：
1999-11-01
影响因子：
6.3
通讯作者：
Goodman-Gruen, D
中科院分区：
文献类型：
--
作者：
Barrett-Connor, E;Goodman-Gruen, D
目的：确定内源性激素水平是否能预测老年妇女的认知功能。设计：一项纵向的、基于人群的研究。地点：加州的兰乔贝尔纳多。参与者：共有393名年龄在55至89岁之间的社区居住妇女，她们没有使用替代雌激素。方法：在1984年和1987年之间，收集血清用于测量总睾酮和生物可利用睾酮、总雌二醇和生物可利用雌二醇以及雌酮。在1988年至1991年期间，进行了12项标准神经心理学测试，包括来自祝福信息记忆集中测试的两个项目，来自Buschke-Fuld选择性提醒测试的三个检索措施，类别流畅性测试，来自视觉再现测试的即时和延迟回忆，简易精神状态检查（MMSE），对序列7和“世界”向后分量进行个体分析，以及轨迹制作测试部分B（轨迹B）。五种激素和12项认知功能测试之间的关联在年龄和教育调整分析中进行了测试，使用线性回归，偏相关，五分位数和分类分析。结果：具有较好MMSE评分（> 23）的女性具有显著更高的调整平均总睾酮和生物可利用睾酮水平（分别为P = .009; P = .02）。使用线性回归，平均总睾酮与MMSE的世界部分的更好表现显著相关（B = 0.12; P = 0.08）。关于雌激素，唯一的统计学意义（P = .02）协会是更好的性能在一个测试中的妇女与非常低水平的雌二醇。结论：在这些老年妇女，更高的内源性雌激素水平与任何认知功能测试显着更好的性能。相比之下，较高水平的睾酮预测更好的分类性能的MMSE和世界的MMSE组成部分。这些新发现值得进一步研究。
OBJECTIVE: To determine if endogenous hormone levels predict cognitive function in older women.DESIGN: A longitudinal, population-based study.SETTING: Rancho Bernardo, California PARTICIPANTS: A total of 393 community-dwelling women aged 55 to 89 years who were not using replacement estrogen.METHODS: Between 1984 and 1987, sera were collected for measurement of total and bioavailable testosterone, total and bioavailable estradiol, and estrone. Between 1988 and 1991, 12 standard neuropsychological tests were administered, including two items from the Blessed Information-Memory-Concentration Test, three measures of retrieval from the Buschke-Fuld Selective Reminding Test, a category fluency test, immediate and delayed recall from the Visual Reproduction Test, the Mini-Mental State Examination (MMSE) with individual analysis of the Serial 7's and the "World" Backwards components, and the Trail-Making Test part B (Trails B). The association between the five hormones and the 12 cognitive function tests was tested in age- and education-adjusted analyses using linear regression, partial correlation, quintile and categorical analyses.RESULTS: Women with better MMSE scores (> 23) had significantly higher adjusted mean total and bioavailable testosterone levels (P = .009; P = .02, respectively). Using linear regression, the mean total testosterone was significantly associated with better performance on the World component of the MMSE (b = .12; P = .08). With regard to estrogen, the only statistically significant (P = .02) association was better performance on one test in women with very low levels of estradiol.CONCLUSIONS: In these older women, higher endogenous estrogen levels were not associated with significantly better performance on any cognitive function test. In contrast, higher levels of testosterone predicted better categorical performance on the MMSE and the World component of the MMSE. These novel findings warrant further research.