Solitary cutaneous nodule of blastic plasmacytoid dendritic cell neoplasm progressing to overt leukemia cutis after chemotherapy: immunohistology and FISH analysis confirmed the diagnosis.
Solitary cutaneous nodule of blastic plasmacytoid dendritic cell neoplasm progressing to overt leukemia cutis after chemotherapy: immunohistology and FISH analysis confirmed the diagnosis.
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母细胞性浆细胞样树突状细胞肿瘤的孤立性皮肤结节在化疗后进展为明显的皮肤白血病：免疫组织学和 FISH 分析证实了诊断。
DOI：
10.1097/dad.0b013e3181a5e13d
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发表时间：
2009
期刊：
影响因子：
--
通讯作者：
C. Neumann
中科院分区：
文献类型：
--
作者：
K. Kaune;M. Baumgart;H. P. Bertsch;C. Mitteldorf;H. Müller;D. Haase;B. Ghadimi;Michael Peter Schön;C. Neumann
母细胞性浆细胞样树突状细胞（BPDC）肿瘤，以前称为母细胞性自然杀伤细胞淋巴瘤或CD 4 +/CD 56+血液皮肤肿瘤，是一种罕见的肿瘤实体，现在被认为是来自浆细胞样树突状细胞（PDC）谱系。由于超过90%的患者通常在疾病早期出现皮肤病变，皮肤科医生必须熟悉这种毁灭性疾病的具体诊断特征和临床过程。我们提出一个长期存在的孤立性皮肤肿瘤的BPDC肿瘤，谁经历了有害的临床过程，这是典型的这种疾病的妇女。表型和核型特征区分这种肿瘤与骨髓单核细胞白血病与皮肤受累。
Blastic plasmacytoid dendritic cell (BPDC) neoplasm, formerly called blastic natural killer cell lymphoma or CD4+/CD56+ hematodermic neoplasm, is a rare tumor entity, now regarded to be derived from the plasmacytoid dendritic cell (PDC) lineage. Because over 90% of patients present with skin lesions usually early in their disease, dermatologists have to be familiar with the specific diagnostic features and the clinical course of this devastating disease. We present a woman with a long standing solitary skin tumor of BPDC neoplasm, who experienced a deleterious clinical course, which is typical for this disease. Phenotypic and karyotypic characteristics distinguishing this tumor from myelomonocytic leukemia with skin involvement are presented.