Brain regions responsive to novelty in the absence of awareness
Brain regions responsive to novelty in the absence of awareness
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DOI：
10.1126/science.276.5316.1272
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发表时间：
1997-05-23
期刊：
影响因子：
56.9
通讯作者：
Mintun, MA
中科院分区：
文献类型：
--
作者：
Berns, GS;Cohen, JD;Mintun, MA
通过正电子发射断层扫描技术绘制了人类在没有意识的情况下对新奇事物做出反应的大脑区域。参与者执行了一项简单的反应时间任务，其中所有刺激都有相同的可能性，但他们不知道，这些刺激遵循一个复杂的序列。行为表现的测量表明，参与者即使不知道任何顺序的存在，也学会了这些顺序。一旦参与者接受了训练，序列性质的微妙且未被察觉的变化就会导致由左前运动区、左前扣带回和右腹侧纹状体组成的网络中的血流量增加。在右侧背外侧前额叶和顶叶区域观察到血流量减少。这些变化的时间过程表明，腹侧纹状体对新信息做出反应，而右前额叶区域与上下文信息的维护相关，这两个过程都可以在无意识的情况下发生。
Brain regions responsive to novelty, without awareness, were mapped in humans by positron emission tomography. Participants performed a simple reaction-time task in which all stimuli were equally likely but, unknown to them, followed a complex sequence. Measures of behavioral performance indicated that participants learned the sequences even though they were unaware of the existence of any order. Once the participants were trained, a subtle and unperceived change in the nature of the sequence resulted in increased blood flow in a network comprising the left premotor area, left anterior cingulate, and right ventral striatum. Blood flow decreases were observed in the right dorsolateral prefrontal and parietal areas. The time course of these changes suggests that the ventral striatum is responsive to novel information, and the right prefrontal area is associated with the maintenance of contextual information, and both processes can occur without awareness.