Occupational exposures and squamous cell carcinoma of the oral cavity, pharynx, larynx, and oesophagus: A case-control study in Sweden
Occupational exposures and squamous cell carcinoma of the oral cavity, pharynx, larynx, and oesophagus: A case-control study in Sweden
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DOI：
10.1136/oem.55.6.393
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发表时间：
1998-06-01
影响因子：
4.9
通讯作者：
Rutkvist, LE
中科院分区：
文献类型：
--
作者：
Gustavsson, P;Jakobsson, R;Rutkvist, LE
Objectives-This社区为基础的病例-参照研究开始调查鳞状细胞癌的上消化道methods-这项研究的病因因素是基于在1988年至1990年期间居住在瑞典的两个地区的40-79岁的瑞典男性。在此基础上，努力确定口腔、口咽和下咽、喉和食管鳞状细胞癌的所有发病病例。参考被选为分层（年龄，地区）随机样本的基础。在病例中的应答率为90%，在参照中的应答率为85%。最终研究组有545例病例和641例参考。研究对象接受了采访，了解几个生活方式因素和职业和工作任务的生活史。17种特定物质的暴露由职业卫生学家编码。癌症的相对危险度（RR）计算logistic回归，标准化年龄，地理区域，酒精和烟草consumption.Results-Exposure石棉与喉癌的风险增加，剂量反应关系。最高暴露组的RR为1.8（95%置信区间（95% CI）I.I至3.0）。超过8年的焊接烟雾暴露与咽癌（RR 2.3（1.1至4.7））和喉癌（RR 2.0（1.0至3.7））的风险增加有关。有迹象表明暴露持续时间存在剂量-反应关系。还发现了多环芳烃（PAHs）高暴露与食管癌的关联，RR为1.9（1.1至3.2）。暴露于木尘与癌症的风险降低，在研究sites.Conclusions-Some目前的研究结果证实已知或怀疑的协会，如石棉和喉癌。这项研究表明，焊接可能会增加患咽癌和喉癌的风险。这些发现证实了暴露于多环芳烃和食管癌之间的联系。
Objectives-This community based case-referent study was initiated to investigate aetiological factors for squamous cell carcinoma of the upper gastrointestinal tract.Methods-The study was based on ah Swedish men aged 40-79 living in two regions of Sweden during 1988-90. Within that base, efforts were made to identify all incident cases of squamous cell carcinoma of the oral cavity, oropharynx and hypopharynx, larynx, and oesophagus. Referents were selected as a stratified (age, region) random sample of the base. The response was 90% among cases and 85% among referents. There were 545 cases and 641 referents in the final study group. The study subjects were interviewed about several Lifestyle factors and a life history of occupations and work tasks. The exposure to 17 specific agents were coded by an occupational hygienist. The relative risk (RR) of cancer was calculated by logistic regression, standardising for age, geographical region, and alcohol and tobacco consumption.Results-Exposure to asbestos was associated with an increased risk of laryngeal cancer, and a dose-response relation was present. The RR was 1.8 (95% confidence interval (95% CI) I.I to 3.0) in the highest exposure group. More than eight years of exposure to welding fumes was associated with an increased risk of pharyngeal cancer (RR 2.3 (1.1 to 4.7)), and laryngeal cancer (RR 2.0 (1.0 to 3.7)). There were indications of a dose-response for duration of exposure. Associations were also found for high exposure to polycyclic aromatic hydrocarbons (PAHs) and oesophageal cancer, RR 1.9 (1.1 to 3.2). Exposure to wood dust was associated with a decreased risk of cancer at the studied sites.Conclusions-Some of the present findings confirm known or suspected associations-such as asbestos and laryngeal cancer. The study indicates that welding may cause an increased risk of pharyngeal as well as laryngeal cancer. The findings corroborate an association between exposure to PAHs and oesophageal cancer.