Synthesis and characterization of a perchlorotriphenylmethyl (trityl) triester radical: A potential sensor for superoxide and oxygen in biological systems
Synthesis and characterization of a perchlorotriphenylmethyl (trityl) triester radical: A potential sensor for superoxide and oxygen in biological systems
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DOI：
10.1016/j.bmcl.2007.04.070
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发表时间：
2007-07-15
影响因子：
2.7
通讯作者：
Kuppusamy, Periannan
中科院分区：
文献类型：
--
作者：
Dang, Vinh;Wang, Jinhua;Kuppusamy, Periannan
报道了惰性全氯三苯基甲基三酯自由基 PTM-TE 的合成和表征。 PTM-TE 通过四氯苯与氯仿的弗里德尔-克来福特反应，然后进行乙氧基羰基化和随后的氧化，通过简单的三步合成来制备。 PTM-TE 具有顺磁性，具有单一的尖锐 EPR 谱。在溶液中，PTM-TE 的 EPR 线宽对溶解氧含量高度敏感，从而能够准确测量氧浓度（血氧测定法）。此外，自由基还对超氧化物表现出高反应性。酯自由基有潜力用作高灵敏探针，用于测定生物系统中的氧浓度和超氧化物。 (C) 2007 Elsevier Ltd. 保留所有权利。
Synthesis and characterization of an inert perchlo rotriphenylmethyl triester radical, PTM-TE, are reported. PTM-TE was prepared by a facile 3-step synthesis using Friedel-Crafts reaction of tetrachlorobenzene with chloroform followed by ethoxycarbonylation and subsequent oxidation. PTM-TE is paramagnetic and exhibits a single sharp EPR spectrum. In solution, the EPR linewidth of PTM-TE is highly sensitive to the dissolved oxygen content, thus enabling accurate measurement of oxygen concentration (oximetry). In addition, the radical also shows high reactivity towards superoxide. The ester radical has the potential for use as a high-sensitive probe for determination of oxygen concentration and superoxide in biological systems. (C) 2007 Elsevier Ltd. All rights reserved.