Entorhinal Layer II Calbindin-Expressing Neurons Originate Widespread Telencephalic and Intrinsic Projections
Entorhinal Layer II Calbindin-Expressing Neurons Originate Widespread Telencephalic and Intrinsic Projections
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DOI：
10.3389/fnsys.2019.00054
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发表时间：
2019-10-15
影响因子：
3
通讯作者：
Witter, Menno P.
中科院分区：
文献类型：
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作者：
Ohara, Shinya;Gianatti, Michele;Witter, Menno P.
在本研究中，我们提供了第一个系统和定量hodological研究的钙结合蛋白表达（CB+）的主要神经元在第二层的内嗅皮层和比较各自的预测的外侧和内侧的内嗅皮层的分区。使用详细的定量逆行追踪，辅以顺行追踪，我们报告说，第二层CB+人口包括不同的，主要是兴奋性的预测神经元。其中至少有一半起源于局部内在和连合投射，主要分布在第一层和第二层。我们进一步表明，从两个内嗅亚部的长距离CB+预测有很大的不同，MEC预测主要针对海马CA1区，而LEC CB+预测分布更广泛，大量的已知前脑目标。LEC和MEC中CB+群体之间的这种连接差异让人想起两个内嗅亚部的整体投影模式。
In the present study we provide the first systematic and quantitative hodological study of the calbindin-expressing (CB+) principal neurons in layer II of the entorhinal cortex and compared the respective projections of the lateral and medial subdivisions of the entorhinal cortex. Using elaborate quantitative retrograde tracing, complemented by anterograde tracing, we report that the layer II CB+ population comprises neurons with diverse, mainly excitatory projections. At least half of them originate local intrinsic and commissural projections which distribute mainly to layer I and II. We further show that long-range CB+ projections from the two entorhinal subdivisions differ substantially in that MEC projections mainly target field CA1 of the hippocampus, whereas LEC CB+ projections distribute much more widely to a substantial number of known forebrain targets. This connectional difference between the CB+ populations in LEC and MEC is reminiscent of the overall projection pattern of the two entorhinal subdivisions.