Ascorbic acid deficiency in patients with lichen planus
Ascorbic acid deficiency in patients with lichen planus
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扁平苔藓患者抗坏血酸缺乏
DOI：
10.1080/15321819.2017.1319863
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发表时间：
2017
影响因子：
--
通讯作者：
S. Georgescu
中科院分区：
文献类型：
--
作者：
I. Nicolae;C. Mitran;M. Mitran;C. Ene;M. Tampa;S. Georgescu
抽象的目标。近年来的研究强调了氧化应激在扁平苔藓（LP）发病机制中的作用。在目前的研究中，作者的兴趣集中在调查LP患者的抗坏血酸状态和确定可能影响这种维生素水平的参数。材料和方法。我们用反射法分析了77例LP患者的尿抗坏血酸水平(皮肤LP (CLP) 49例；口服LP (OLP) 28例，对照组50例。对所有参与者的评估包括临床检查、实验室检查和影像学检查。结果。与对照组（19.82 mg/dl）相比，CLP患者（8.47 mg/dl, p = 0.001）和OLP患者（8.04 mg/dl, p = 0.001）的抗坏血酸水平均显著降低。LP患者抗坏血酸缺乏随年龄增加而增加（r = -0.318, p = 0.032）。与未感染的LP患者相比，与感染相关的LP患者尿中抗坏血酸浓度显著降低。结论。尿抗坏血酸水平可能是识别LP患者是否有病毒或细菌感染风险的有用参数。
ABSTRACT Objectives. Recent studies have highlighted the role of oxidative stress in the pathogenesis of lichen planus (LP). In the present study, the interest of the authors is focused on the investigation of ascorbic acid status in patients with LP and identification of parameters that might influence the level of this vitamin. Material and method. We analyzed the level of urinary ascorbic acid (reflectometric method) in 77 patients with LP (cutaneous LP (CLP)—49 cases; oral LP (OLP)—28 cases) and 50 control subjects. The evaluation of all participants included clinical examination and laboratory and imaging tests. Results. Compared to the control group (19.82 mg/dl) the level of ascorbic acid was significantly lower both in patients with CLP (8.47 mg/dl, p = 0.001) and in those with OLP (8.04 mg/dl, p = 0.001). In patients with LP it was found that the deficiency of ascorbic acid increases with age (r = -0.318, p = 0.032). The urinary concentrations of ascorbic acid were significantly lower in patients with LP associated with infections compared to patients with LP without infections. Conclusions. The urinary ascorbic acid level may be a useful parameter in identifying patients with LP who are at risk of developing viral or bacterial infections.