Lipase-mediated resolution of 4-TMS-3-butyn-2-ol and use of the mesylate derivatives as a precursor to a highly stereoselective chiral allenylindium reagent.
Lipase-mediated resolution of 4-TMS-3-butyn-2-ol and use of the mesylate derivatives as a precursor to a highly stereoselective chiral allenylindium reagent.
复制标题
脂肪酶介导的 4-TMS-3-丁炔-2-醇的拆分以及使用甲磺酸酯衍生物作为高度立体选择性手性联烯基试剂的前体。
DOI：
10.1021/ol016605x
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发表时间：
2001
期刊：
影响因子：
5.2
通讯作者：
Yanik,MM
中科院分区：
文献类型：
--
作者：
Marshall,JA;Chobanian,HR;Yanik,MM
改进了4-三甲基硅基-3-丁基-2-醇的拆分方法。已发现拆分的醇的甲酸盐衍生物与醛发生高度的对映体、区域和非对映选择性加成反应，生成高丙基醇加合物。
An improved procedure for the resolution of 4-trimethylsilyl-3-butyn-2-ol has been developed. The mesylate derivatives of the resolved alcohols have been found to undergo highly enantio-, regio-, and diastereoselective additions to aldehydes, leading to homopropargylic alcohol adducts.