Biochemical and behavioral effects of a sensorimotor cortex injury in rats pretreated with the noradrenergic neurotoxin DSP-4.
Biochemical and behavioral effects of a sensorimotor cortex injury in rats pretreated with the noradrenergic neurotoxin DSP-4.
复制标题
用去甲肾上腺素能神经毒素 DSP-4 预处理的大鼠感觉运动皮层损伤的生化和行为影响。
DOI：
10.1037//0735-7044.106.6.964
复制
发表时间：
1992
影响因子：
1.9
通讯作者：
Cavazos,JE
中科院分区：
文献类型：
--
作者：
Boyeson,MG;Callister,TR;Cavazos,JE
研究了去甲肾上腺素能（NE）系统在感觉运动皮层（SMCX）损伤后运动功能恢复中的作用。在进行梁行走任务训练以评估运动功能变化后，给予动物DSP-4或生理盐水并测试2周;然后两组均接受单侧SMCX抽吸消融。与生理盐水组相比，接受DSP-4的动物在运动恢复方面显著延迟。在损伤后24天（运动恢复后），动物的缺陷显着恢复NE阻断药物。DSP-4显著降低海马和小脑中的NE水平。Timm组织化学分析显示，在用DSP-4预处理的动物的海马中，海马神经元发芽，这表明在其他途径中可能发生类似的海马神经元可塑性的可能性，并且在DSP-4诱导的NE去传入后，兴奋性毒性也可能发挥作用。
The role of the noradrenergic (NE) system in recovery of motor function after sensorimotor cortex (SMCX) injury was investigated. After training on a beam-walking task to assess changes in motor function, animals were given DSP-4 or saline and tested for 2 weeks; both groups then received unilateral SMCX suction ablations. Animals that received DSP-4 were significantly retarded in motor recovery compared with the saline group. At 24 days after injury (after motor recovery), the animals' deficits were significantly reinstated with NE-blocking drugs. DSP-4 significantly depressed NE levels in the hippocampus and cerebellum. A Timm histochemical analysis revealed glutamatergic sprouting in the hippocampus of animals that were pretreated with DSP-4, which suggests the possibility that similar glutamatergic plasticity in other pathways may occur and that excitotoxicity might also play a role after the DSP-4 induced NE deafferentation.