The molecular biology of the cell : B. Alberts, D. Bray, J. Lewis, M. Raff, K. Roberts and J.D. Watson Garland Publishing; New York, London, 1983 xxxix + 1181 pages. $33.95 (hardback); $27.00, £14.95 (paperback, only in Europe)
The molecular biology of the cell : B. Alberts, D. Bray, J. Lewis, M. Raff, K. Roberts and J.D. Watson Garland Publishing; New York, London, 1983 xxxix + 1181 pages. $33.95 (hardback); $27.00, £14.95 (paperback, only in Europe)
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DOI：
10.1016/0014-5793(86)80238-1
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发表时间：
1986-02
期刊：
影响因子：
3.5
通讯作者：
H. Arnstein
中科院分区：
文献类型：
--
作者：
H. Arnstein
在过去的大约40年里，关于细胞结构和功能的分子基础的信息有了爆炸性的增长。如果要保持目前的进步速度，就必须把新的发现融入到连贯的知识体系中，这样学生才能从新的、更先进的角度进行教学。在吸收新知识的过程中，教材起到了至关重要的作用，这本涉及面很广的书是一个突出的贡献。本课程主要面向学习细胞生物学第一门课程的本科生、研究生或医科学生，其一般方法强调通过整合从完整细胞(细胞生物学)及其分子成分(分子生物学和生物化学)研究中获得的信息，在多细胞动植物的组织、功能和发育中涉及的原理的分子方面。这是一本很大的书，分为三个部分，标题为细胞导论、细胞的分子组织和从细胞到多细胞生物体。导言介绍了真核细胞的多样性、亚细胞结构和发育，以及研究细胞的方法，包括显微镜、细胞培养、放射性示踪剂的使用和重组DNA技术。在分子方面，讨论了细胞的基本化学成分，包括小分子和大分子，以及它们的代谢以及细胞能量的产生和利用。第二部分更详细地介绍了细胞的结构和功能，包括质膜、亚细胞结构、基本遗传机制、细胞周期、细胞间黏附和细胞间化学信号的九章。这些章节涉及的分子方面包括蛋白质和RNA的合成、DNA复制和修复、病毒、基因表达的控制、膜结构、激素、神经递质和其他化学介质，以及麻省理工学院~Hond~a和~a叶绿体中的能量转换。在第三部分的六章中，重点介绍了多细胞生物体的发展：生殖细胞与受精、干细胞与分化、免疫系统、神经系统以及最后但并非最不重要的植物细胞的特性。在这一部分，大部分材料涉及细胞方面，但免疫球蛋白、神经传递和植物细胞多样性的结构和生成的分子方面也被详细涵盖。这本书显然与JD Watson的分子生物学一样高水准，以有趣和清晰的风格涵盖选定的主题。正文补充了大约1285张清晰的图表和漂亮的照片，这些图片通过说明重要的观点构成了宝贵的补充。其他有用的功能包括相关章节结尾处的主题摘要和每章结尾处的参考文献列表，给出教科书的一般参考文献和研究论文的具体引用。
In the last 40 years or so there has been an explosive increase in information about the molecular basis of cell structure and function. If the current rate of progress is to be m~ nt~ ned, new discoveries have to be integrated into a coherent body of knowledge so that students can be taught from a new and more advanced perspective. In this process of assimilating new knowledge textbooks play an essential part and this wideranging book is an outstanding contribution. It is intended primarily for undergraduates, postgraduate students or medical students taking a first course in cell biology and its general approach emphasizes molecular aspects of the principles involved in the organization, function and development of multicellular animals and plants by integrating information obtained from studies of intact cells (cell biology) and their molecular constituents (molecular biology and biochemistry). It is a large book, divided into three parts entitled Introduction to the Cell, The Molecular Organization of the Cell and From Cells to Multicellular Organisms. The introduction describes the diversity of eukaryotic cells, their subcellular structure and development, and methods for studying cells, including microscopy, cell culture, the use of radioactive tracers and recombinant DNA technology. On the molecular side the basic chemical components of cells, including both small molecules and macromol~ ules, and their metabolism are discussed as well as the generation and use of cellular energy. Part II deals in more detail with cell structure and function and includes nine chapters on the plasma membrane, subcellular structures, basic genetic mechanisms, the cell cycle, cell-cell adhesion and chemical signals between cells. Molecular aspects covered in these chapters include protein and RNA synthesis, DNA replication and repair, viruses, control of gene expression, membrane structure, hormones, neurotransmitters and other chemical mediators, and energy conversion in mit~ hond~ a and~ hloroplasts. In the six chapters of part III the emphasis is on the development of multicellular organisms: germ cells and fertilization, stem cells and differentiation, the immune system, the nervous system and last but not least special features of plant cells. In this section most of the material deals with cellular aspects but molecular aspects of the structure and generation of diversity of immunoglobulins, neurotransmission and plant cells are also covered in detail.This book is clearly of the same high calibre as JD Watson’s Mol~ ular Biology of the Gene and covers the selected topics in an interesting and lucid style. The text is supplemented by some 1285 clear diagrams and beautiful photographs, which constitute a valuable addition by illustrating important points. Other useful features include the summaries of topics at the end of relevant sections and lists of references at the end of each chapter, giving both general references to textbooks and specific citations to research papers