Anamnestic Development of Lymphocytic Infiltration in Murine Experimental Autoimmune Oophoritis Is Primarily Localized in the Stroma and Theca
Anamnestic Development of Lymphocytic Infiltration in Murine Experimental Autoimmune Oophoritis Is Primarily Localized in the Stroma and Theca
复制标题
小鼠实验性自身免疫性卵巢炎中淋巴细胞浸润的记忆发展主要位于间质和卵泡膜
DOI：
10.1111/j.1600-0897.1995.tb00928.x
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发表时间：
1995
影响因子：
3.6
通讯作者：
L. Nelson
中科院分区：
文献类型：
--
作者：
Shailaja Raj;S. Nair;G. Mastorakos;L. Nelson
PROBLEM: Neonatal thymectomy performed on day 3 of life (NTX3) induces autoimmune oophoritis and ovarian failure in B6A mice. These mice develop high‐titer autoantibodies specific to oocytes, and ultimately the ovaries become fibrotic and devoid of primordial follicles. These findings implicate the oocyte as a primary target of the autoimmune process. However, in previous work we demonstrated that in developing disease the lymphocytic infiltration was confined to the stroma and theca, and not found involving oocytes. Here, we investigate the possibility that lymphocytic infiltration involving oocytes develops as part of end‐stage disease.
新生儿胸腺切除引起的自身免疫性卵巢炎的效应细胞和调节细胞。
DOI：
--
发表时间：
1991
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Smith,H;Sakamoto,Y;Kasai,K;Tung,KS
通讯作者：
Tung,KS
影响因子：
15.9
作者：
RHIM, SH;MILLAR, SE;TUNG, KSK
通讯作者：
TUNG, KSK