Relationship between circulating FGF23 and total body atherosclerosis in the community
Relationship between circulating FGF23 and total body atherosclerosis in the community
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DOI：
10.1093/ndt/gfp205
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发表时间：
2009-10-01
影响因子：
6.1
通讯作者：
Larsson, Tobias E.
中科院分区：
文献类型：
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作者：
Mirza, Majd A. I.;Hansen, Tomas;Larsson, Tobias E.
背景成纤维细胞生长因子-23（FGF 23）是矿物质代谢的调节因子，并已被认为在慢性肾脏疾病（CKD）的血管钙化中发挥作用。在CKD和社区中，FGF 23和动脉粥样硬化之间相关性的数据有限。通过基于磁共振成像的血管造影术确定了306名老年男性和女性的全身动脉粥样硬化评分（AS），这些老年男性和女性代表了基于社区的PIVUS队列的子样本。根据AS将受试者分为三类：AS = 0、低AS和高AS。采用双位点单克隆抗体ELISA法检测血清FGF 23水平。在连续和多类别回归模型中，较高的FGF 23与高AS的几率显著增加相关（OR 1.43，CI 1.06-1.92至OR 3.01，CI 1.52-5.99）。在eGFR < 60 mL/min/1.73 m2的个体中，这种关联更强（n = 27），在FGF 23上三分位数中，高AS的几率增加了近6倍（OR 5.64，CI 2.78-11.5）。我们发现FGF 23和动脉粥样硬化之间的关系支持较弱，因为在原始模型中，FGF 23最高三分位数的受试者AS > 0的风险增加（OR 1.93，CI 1.05-3.55），但在校正模型中，这在统计学上并不显著（OR 1.42，CI 0.74-1.72）。我们提供了新的证据支持血清FGF 23和全身动脉粥样硬化之间的联系在社区。进一步的研究是必要的，以确定FGF 23和动脉粥样硬化之间的前瞻性关系，以及FGF 23是否是一个可改变的心血管危险因素。
Background. Fibroblast growth factor-23 (FGF23) is a regulator of mineral metabolism and has been suggested to play a role in vascular calcification in chronic kidney disease (CKD). Data on the association between FGF23 and atherosclerosis, both in CKD and in the community, is limited.Methods. The total body atherosclerosis score (AS) was determined by a magnetic resonance imaging-based angiography in 306 elderly men and women, representing a subsample of the community-based PIVUS cohort. Subjects were divided into three categories based on AS: AS = 0, low AS and high AS. Serum FGF23 was measured using a two-site monoclonal antibody ELISA.Results. In continuous and multi-category regression models, higher FGF23 was associated with a significant increase in the odds of having a high AS (OR 1.43, CI 1.06-1.92 to OR 3.01, CI 1.52-5.99). This association was stronger in individuals with eGFR < 60 mL/min/1.73 m(2) (n = 27), reaching a nearly 6-fold increase in the odds for a high AS in the upper FGF23 tertile (OR 5.64, CI 2.78-11.5). We found weaker support for a relationship between FGF23 and the presence of atherosclerosis as subjects in the highest FGF23 tertile had an increased risk for an AS > 0 in crude models (OR 1.93, CI 1.05-3.55), but this was not statistically significant in adjusted (OR 1.42, CI 0.74-1.72) models.Conclusions. We provide novel evidence supporting an association between serum FGF23 and total body atherosclerosis in the community. Additional studies are warranted to determine the prospective relationship between FGF23 and atherosclerosis, and whether FGF23 is a modifiable cardiovascular risk factor.