Prognostic impact of neutrophils-to-lymphocytes ratio (NLR), PD-L1 expression, and tumor immune microenvironment in laryngeal cancer
Prognostic impact of neutrophils-to-lymphocytes ratio (NLR), PD-L1 expression, and tumor immune microenvironment in laryngeal cancer
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DOI：
10.1016/j.anndiagpath.2020.151657
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发表时间：
2021-02-01
影响因子：
2
通讯作者：
Marioni, Gino
中科院分区：
文献类型：
--
作者：
Franz, Leonardo;Alessandrini, Lara;Marioni, Gino
目的：随着喉癌免疫治疗的进展，肿瘤免疫微环境的研究日益受到关注。由于肿瘤抗原诱导的免疫反应，免疫细胞迁移至肿瘤，并且癌细胞募集免疫调节细胞以诱导免疫抑制网络，导致逃避宿主免疫。这种相互作用反映了肿瘤微环境和全身炎症状态。血嗜中性粒细胞/淋巴细胞比率（NLR）反映了高度的促炎状态，与较差的肿瘤学生存结局相关。（也在NLR方面）和肿瘤免疫微环境组织病理学特征（程序性细胞死亡配体1 [PD-L1]表达和肿瘤浸润性淋巴细胞[TIL]），还研究了它们的临床病理学和预后意义。对60例连续的LSCC患者进行术前血液NLR、病理检查、PD-L1（联合阳性评分[CPS]）和TIL评估。结果：血液NLR、中性粒细胞和淋巴细胞计数在预测DFS和复发风险方面具有显著价值。此外，PD-L1 CPS >= 1和TIL计数率>= 30%与更高的无病生存率（DFS）和更低的复发风险相关。逻辑回归模型发现NLR值增加与PD-L1 CPS < 1和TIL计数率之间存在显著正相关
Purpose: In laryngeal carcinoma (LSCC), tumor immune microenvironment is attracting increasing interest, given the recent progresses in immunotherapy. Immune cells migrate to tumors as a result of a tumor antigen-induced immune reaction and cancer cells recruit immune regulatory cells to induce an immunosuppressive network, resulting in the escape from host immunity. This interaction reflects both on tumor microenvironment and systemic inflammatory status. Blood neutrophil-to-lymphocyte ratio (NLR), reflecting a highly pro-inflammatory status, has been related to worse oncological survival outcomes.The aim of this study was to analyze in LSCC the relationship between circulating inflammatory cells (also in terms of NLR) and tumor immune microenvironment histopathological features (programmed cell death ligand 1 [PD-L1] expression, and tumor-infiltrating lymphocytes [TILs]), also investigating their clinical-pathological and prognostic significance.Methods: Blood pre-operative NLR, and, at pathology, PD-L1 (in terms of combined positive score [CPS]) and TILs were assessed on 60 consecutive cases of LSCC.Results: Blood NLR, neutrophils, and lymphocytes counts showed a significant value in predicting DFS and recurrence risk. Moreover, PD-L1 CPS >= 1 and TILs count rate >= 30% were associated with higher disease-free survival (DFS) and reduced recurrence risk. A logistic regression model found a significant positive association between increasing NLR values, and PD-L1 CPS < 1 and TILs count rate