RHEUMATOID LYMPHADENOPATHY
RHEUMATOID LYMPHADENOPATHY
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DOI：
10.1136/ard.27.3.253
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发表时间：
1968-01-01
影响因子：
27.4
通讯作者：
BOARDMAN, PL
中科院分区：
文献类型：
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作者：
ROBERTSON, MD;HART, FD;BOARDMAN, PL
Chauffard和Ramond（1896）被认为是第一个描述类风湿性关节炎患者发生淋巴结病的人。这种联系已被其他人证实（麦克雷，1904年；沃特豪斯，1908年；科茨和德利卡蒂，1931年；帕克斯·韦伯，1944年；罗特-奎罗和Ciscar Ruis， 1948年；莫图尔斯基，温伯格，萨菲尔和罗森博格，1952年；费尔德曼，1961年；马卡伦科，1965年），并已被普遍接受。虽然淋巴结病变被认为是斯蒂尔氏病和费尔蒂氏综合征的内在特征，但对于其在类风湿关节炎中的整体意义尚未达成普遍共识。Short， Bauer和Reynolds（1957）在他们对类风湿关节炎临床特征的经典研究中发现，在当时发表的报告中，淋巴结病的发病率从19%到96%不等。在他们自己的86名患者系列中，29%的患者有明显的淋巴结肿大，而26名对照受试者中有8% - 9%。他们注意到男性发病率较高，但没有发现与疾病活动、发病类型或疾病的后续病程相关，他们也没有试图确定淋巴结的大小，这些淋巴结的大小是重要的，也没有试图将淋巴结病与疾病持续时间和局部关节活动联系起来。已对类风湿病患者进行淋巴管造影，但对于典型症状的构成及其意义尚未达成普遍共识（Malek, Belan, Kriegel, and Kolc, 1960; Lucherini, bomi -piani, Porzio, and Spina, 1965; Michotte and van Bogaert, 1966; Wiljasalo, Julkunen, and Salven, 1966）。
Chauffard and Ramond (1896) are credited with the first description of lymphadenopathy occurring in patients with rheumatoid arthritis. The associa-tion has been confirmed by others (McCrae, 1904; Waterhouse, 1908; Coates and Delicati, 1931; Parkes Weber, 1944; Rotes-Querol and Ciscar Ruis, 1948; Motulsky, Weinberg, Saphir, and Rosenberg, 1952; Feldman, 1961; Makarenko, 1965), and has become generally accepted. Although lymphadenopathy is considered to be an intrinsic feature of Still's disease and Felty's syndrome, there is no general agreement as to its significance in rheuma-toid arthritis as a whole. Short, Bauer, and Reynolds (1957), in their classic study of the clinical features of rheumatoid arthritis, found that the incidence of lymphadenopathy varied from 19 to 96 per cent. in reports published at that time. In their own series of 86 patients, 29-4 per cent. had significant lymph node enlargement compared with 8-9 per cent. of 26 control subjects. They noted a higher incidence in males, butcould find no correlation with disease activity, type of onset, or subsequent course of the disease, and they made no attempt to define the sizes of lymph nodes which were signifificant, or to correlate lymphadenopathy with dura-tion of disease and local joint activity. Lymphangiography has been performed on patients with rheumatoid disease, but there is no general agreement on what constitutes the typical appearances or what their significance is (Malek, Belan, Kriegel, and Kolc, 1960; Lucherini, Bom-piani, Porzio, and Spina, 1965; Michotte and van Bogaert, 1966; Wiljasalo, Julkunen, and Salven, 1966).