Quantitative analysis and inspection for pharmaceutical polymorphism with injection-seeded terahertz parametric generation technique
Quantitative analysis and inspection for pharmaceutical polymorphism with injection-seeded terahertz parametric generation technique
复制标题
注射种子太赫兹参数生成技术对药物多态性的定量分析和检测
DOI：
10.1109/irmmw-thz.2018.8510222
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
T. Ono
中科院分区：
文献类型：
--
作者：
M. Mohara;K. Aiko;K. Shimura;T. Ono
太赫兹（THz）波谱注射种子太赫兹参数产生技术（is- TPG）由于太赫兹波峰功率高、动态范围宽，有潜力成为一种药品片剂无损透射检测技术。利用is- tpg技术，通过吸收峰对马来酸依那普利多晶和非诺洛芬钙晶体进行了鉴定。对这些样品进行定量分析。非诺洛芬钙晶体的检出限为0.14 wt%。
Terahertz (THz) spectroscopy with injection-seeded terahertz parametric generation (is- TPG) technique has potential as a nondestructive transmission inspection technique for pharmaceutical tablets because of high peak power THz wave and wide dynamic range. Using a spectrometer with is- Tpgtechnique, enalapril maleate polymorphs and fenoprofen calcium crystalline were identified by their specific absorption peaks. Quantitative analysis of these samples were conducted. The limit of detection of 0.14 wt% of fenoprofen calcium crystalline was obtained.