GENERATION OF ELECTRIC POTENTIALS BY BONE IN RESPONSE TO MECHANICAL STRESS
GENERATION OF ELECTRIC POTENTIALS BY BONE IN RESPONSE TO MECHANICAL STRESS
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DOI：
10.1126/science.137.3535.1063
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发表时间：
1962-01-01
期刊：
影响因子：
56.9
通讯作者：
BECKER, RO
中科院分区：
文献类型：
--
作者：
BASSETT, CAL;BECKER, RO
在应力骨中产生的电势的幅度取决于骨变形的速率和幅度，而极性由弯曲的方向决定。相对于其他区域，受压区域发展出负电位。在活骨和死骨中获得了类似的结果。从骨中去除无机部分会破坏其产生应力电位的能力。这些电位可能直接影响骨细胞的活性。此外，可以想象，它们可以（以某种方式）指导细胞外基质的大分子的聚集模式。
The amplitude of electrical potentials generated in stressed bone is dependent upon the rate and magnitude of bony deformation, while polarity is determined by the direction of bending. Areas under compression develop negative potentials with respect to other areas. Similar results were obtained both in living and dead bone. Removal of the inorganic fraction from bone abolishes its ability to generate stress potentials. It is probable that these potentials influence the activity of osseous cells directly. Furthermore, it is conceivable that they may direct (in some manner) the aggregation pattern of the macromolecules of the extracellular matrix.