FINE STRUCTURE OF EXOERYTHROCYTIC STAGES OF PLASMODIUM FALLAX
FINE STRUCTURE OF EXOERYTHROCYTIC STAGES OF PLASMODIUM FALLAX
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DOI：
10.1083/jcb.30.2.333
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发表时间：
1966-01-01
影响因子：
7.8
通讯作者：
SPRINZ, H
中科院分区：
文献类型：
--
作者：
HEPLER, PK;HUFF, CG;SPRINZ, H
已分析了使用来自胚胎火鸡脑细胞的组织培养系统中生长的制剂，固定在戊二醛-OsO 4中的禽疟疾寄生虫，疟原虫fallax的外红细胞周期的精细结构。成熟的裂殖子是一个长3- 4 [mu]，宽1- 2 [mu]的细长细胞，被包裹在一个复杂的双层表膜中。前端由圆锥体组成，从中发出两个分裂的成对细胞器和几个紧密相连的致密体。细胞核位于细胞的中部，而在后端发现一个包裹着球形体的单细胞核。裂殖子的表膜上靠近核的地方有一个直径为80 ~ 100 μ m的细胞气孔腔。根据细胞精细结构的变化，将其发育过程分为三个阶段：去分化阶段，裂殖子失去许多复杂的结构，如圆锥体、成对细胞器、致密体、球状体和厚的表膜内层，转变为滋养体;第二，生长期，包括许多核分裂以及线粒体、内质网和核糖体的平行增加;第三阶段为红分化和细胞质分裂期，此时随着新的裂殖子从母裂殖子上出芽，特化的细胞器重新出现。
The fine structure of the exoerythrocytic cycle of an avian malarial parasite, Plasmodium fallax, has been analyzed using preparations grown in a tissue culture system derived from embryonic turkey brain cells which were fixed in glutaraldehyde-OsO4. The mature merozoite, an elongated cell 3- to 4-[mu] long and 1- to 2-[mu] wide, is ensheathed in a complex doublelayered pellicle. The anterior end consists of a conoid, from which emanate two lobed paired organelles and several closely associated dense bodies. A nucleus is situated In the mid portion of the cell, while a single mitochondrion wrapped around a spherical body is found in the posterior end. On the pellicle of the merozoite near the nucleus a cytostomal cavity, 80 to 100 mix in diameter, is located. Based on changes in fine structure, the subsequent sequence of development is divided into three phase first, the dedifferentlation phase, in which the merozoite loses many complex structures, i.e. the conoid, paired organelles, dense bodies, spherical body, and the thick inner layers of the pellicle, and transforms into a trophozoite; second, the growth phase, which consists of many nuclear divisions as well as parallel increases in mitochondria, endoplasmic reticulura, and ribosomes; and third, the redlfferentiation and cytoplasmic schizogony phase, in which the specialized organelles reappear as the new merozoites bud off from the mother schizont.