Cisplatin combination chemotherapy induces oxidative stress in advance non small cell lung cancer patients.
Cisplatin combination chemotherapy induces oxidative stress in advance non small cell lung cancer patients.
复制标题
DOI：
--
复制
发表时间：
2010
期刊：
影响因子：
--
通讯作者：
A. Srivastava;Abhilasha Gupta;S. Srivastava;SM Natu;B. Mittal;Mps Negi;R. Prasad
中科院分区：
文献类型：
--
作者：
A. Srivastava;Abhilasha Gupta;S. Srivastava;SM Natu;B. Mittal;Mps Negi;R. Prasad
本研究前瞻性地测定了以顺铂为基础的联合化疗对晚期非小细胞肺癌（NSCLC）患者的氧化应激和生存率的影响。材料与方法对144例对照组和203例新诊断的晚期（IIIA/IIIB/IV）NSCLC患者在治疗前（第0天）、化疗第3、6周期后的氧化应激水平（LPO、NO、GSH和SOD）进行了评估。组间比较采用重复测量方差分析，生存曲线比较采用Kaplan-Meier法。结果与对照组比较，治疗前患者血清LPO、NO水平显著升高（P<0.01），GSH、SOD水平显著降低（P<0.01）。化疗后氧化应激水平明显升高（P<0.01），且高分期患者较低分期患者更明显。IV期患者的2年总生存率（%）显著低于III A和III B期患者（P<0.05）。IV期患者的比例死亡率也最高（37.0%），其次是III期B（31.7%）和III A（20.0%）。结论以顺铂为基础的联合化疗可诱导非小细胞肺癌患者产生氧化应激反应。
BACKGROUND This study determine oxidative stress and survival prospectively in advanced stage non small cell lung cancer (NSCLC) patients following cisplatin based combination chemotherapy. MATERIALS AND METHODS The oxidative stress levels (LPO, NO, GSH and SOD) of 144 control subjects and 203 advanced stage (IIIA/IIIB/IV) newly diagnosed NSCLC patients were assessed at pre-treatment (day '0'), and after the 3rd and 6th cycles of chemotherapy. Groups were compared by repeated measures ANOVA while comparison of survival curves was conduced by Kaplan-Meier methods. RESULTS The pre-treatment mean levels of LPO and NO in patients were significantly (P<0.01) higher while GSH and SOD were significantly (P<0.01) lower as compared to control. The oxidative stress was elevated more significantly (P<0.01) after the chemotherapy and was more evident in higher stage than lower stage patients. The two year overall survival (%) of stage IV patients was significantly lower (P<0.05) as compared to stage III A and III B. The proportional mortality was also maximal in stage IV patients (37.0%) followed by stage III B (31.7%) and III A (20.0%). CONCLUSION Cisplatin based combination chemotherapy induces oxidative stress in NSCLC patients.